TY - JOUR
T1 - Ovarian malignant mixed müllerian tumors treated with platinum-based chemotherapy
AU - Bicher, Annette
AU - Levenback, Charles
AU - Silva, Elvio G.
AU - Burke, Thomas W.
AU - Morris, Mitchell
AU - Gershenson, David M.
PY - 1995
Y1 - 1995
N2 - Objective: To characterize the clinical course of patients diagnosed with ovarian malignant mixed müllerian tumors treated with platinum-based chemotherapy. Methods: Thirty-six patients received this treatment at The University of Texas M. D. Anderson Cancer Center in the period 1979–1993. The mean age was 59 years. Stage distribution was as follows: stage IA, one (3%) patient; stage IIIII, two (5.5%); stage IIIC, 21 (58%); and stage IV, two (5.5%). Ten (28%) patients were unstaged. Chemotherapy regimens included cisplatin, doxorubicin, and cyclophosphamide in 16 patients; cisplatin-ifosfamide in five; cisplatin-cyclophosphamide in four, carboplatinum in three; cisplatindoxorubicin in three; and various other combinations in the remaining five. Results: Of 16 patients evaluated for clinical response, seven (44%) had a complete response and four (25%) had a partial response, for a total clinical response rate of 69%. Nine patients were evaluated for surgical response: five (56%) had a complete response and one (11%) had a partial response, for a total surgical response rate of 67%. The median survival for the cohort was 18 months. At the time of this analysis, five (14%) patients were alive and disease-free, 25 (69%) had died of disease, five (14%) were alive with disease, and one had been lost to follow-up. Conclusion: This study suggests that the clinical course of patients with ovarian malignant mixed müllerian tumors treated with platinum-based chemotherapy is similar to the clinical course experienced by patients with high-grade epithelial carcinoma of the ovary.
AB - Objective: To characterize the clinical course of patients diagnosed with ovarian malignant mixed müllerian tumors treated with platinum-based chemotherapy. Methods: Thirty-six patients received this treatment at The University of Texas M. D. Anderson Cancer Center in the period 1979–1993. The mean age was 59 years. Stage distribution was as follows: stage IA, one (3%) patient; stage IIIII, two (5.5%); stage IIIC, 21 (58%); and stage IV, two (5.5%). Ten (28%) patients were unstaged. Chemotherapy regimens included cisplatin, doxorubicin, and cyclophosphamide in 16 patients; cisplatin-ifosfamide in five; cisplatin-cyclophosphamide in four, carboplatinum in three; cisplatindoxorubicin in three; and various other combinations in the remaining five. Results: Of 16 patients evaluated for clinical response, seven (44%) had a complete response and four (25%) had a partial response, for a total clinical response rate of 69%. Nine patients were evaluated for surgical response: five (56%) had a complete response and one (11%) had a partial response, for a total surgical response rate of 67%. The median survival for the cohort was 18 months. At the time of this analysis, five (14%) patients were alive and disease-free, 25 (69%) had died of disease, five (14%) were alive with disease, and one had been lost to follow-up. Conclusion: This study suggests that the clinical course of patients with ovarian malignant mixed müllerian tumors treated with platinum-based chemotherapy is similar to the clinical course experienced by patients with high-grade epithelial carcinoma of the ovary.
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U2 - 10.1016/0029-7844(95)00038-S
DO - 10.1016/0029-7844(95)00038-S
M3 - Article
C2 - 7724104
AN - SCOPUS:0028897825
SN - 0029-7844
VL - 85
SP - 735
EP - 739
JO - Obstetrics and gynecology
JF - Obstetrics and gynecology
IS - 5
ER -