Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma

Jieyu Zhou; Yongmei Li; Dongmin Wei; Ye Qian; Wenming Li; Dayu Liu; Guojun Li; Xinliang Pan; Dapeng Lei

doi:10.3892/or.2015.4313

Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma

Jieyu Zhou, Yongmei Li, Dongmin Wei, Ye Qian, Wenming Li, Dayu Liu, Guojun Li, Xinliang Pan, Dapeng Lei

Head & Neck Surgery

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

The aims of the present study were to review the experience of different surgical reconstruction methods for hypopharyngeal squamous cell carcinoma (HSCC) and compared the survival of patients with and without laryngeal function (LF) preservation. The clinical characteristics of 580 patients were retrospectively obtained and analyzed. Survival curves were analyzed using the Kaplan-Meier method for survival and Cox models for hazard ratios (HRs) with 95% confidence intervals (CIs). LF was preserved in 403 cases and not preserved in 177 cases. The 3- and 5-year survival rates were 70.9 and 52.7%, respectively, in the LF preservation group and 48.4 and 30.5%, respectively, in the no LF preservation group. Compared with the patients without LF preservation, patients with LF preservation had a significantly reduced risk of overall death (HR=0.63, 95% CI: 0.50-0.80). LF preservation positively affects the prognosis of patients with HSCC.

Original language	English (US)
Pages (from-to)	3196-3202
Number of pages	7
Journal	Oncology reports
Volume	34
Issue number	6
DOIs	https://doi.org/10.3892/or.2015.4313
State	Published - Dec 1 2015

Keywords

Combined modality therapy
Function preservation
Hypopharyngeal squamous cell carcinoma
Laryngectomy
Pharyngectomy
Quality of life
Survival

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma",

abstract = "The aims of the present study were to review the experience of different surgical reconstruction methods for hypopharyngeal squamous cell carcinoma (HSCC) and compared the survival of patients with and without laryngeal function (LF) preservation. The clinical characteristics of 580 patients were retrospectively obtained and analyzed. Survival curves were analyzed using the Kaplan-Meier method for survival and Cox models for hazard ratios (HRs) with 95% confidence intervals (CIs). LF was preserved in 403 cases and not preserved in 177 cases. The 3- and 5-year survival rates were 70.9 and 52.7%, respectively, in the LF preservation group and 48.4 and 30.5%, respectively, in the no LF preservation group. Compared with the patients without LF preservation, patients with LF preservation had a significantly reduced risk of overall death (HR=0.63, 95% CI: 0.50-0.80). LF preservation positively affects the prognosis of patients with HSCC.",

keywords = "Combined modality therapy, Function preservation, Hypopharyngeal squamous cell carcinoma, Laryngectomy, Pharyngectomy, Quality of life, Survival",

author = "Jieyu Zhou and Yongmei Li and Dongmin Wei and Ye Qian and Wenming Li and Dayu Liu and Guojun Li and Xinliang Pan and Dapeng Lei",

year = "2015",

month = dec,

day = "1",

doi = "10.3892/or.2015.4313",

language = "English (US)",

volume = "34",

pages = "3196--3202",

journal = "Oncology reports",

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TY - JOUR

T1 - Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma

AU - Zhou, Jieyu

AU - Li, Yongmei

AU - Wei, Dongmin

AU - Qian, Ye

AU - Li, Wenming

AU - Liu, Dayu

AU - Li, Guojun

AU - Pan, Xinliang

AU - Lei, Dapeng

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The aims of the present study were to review the experience of different surgical reconstruction methods for hypopharyngeal squamous cell carcinoma (HSCC) and compared the survival of patients with and without laryngeal function (LF) preservation. The clinical characteristics of 580 patients were retrospectively obtained and analyzed. Survival curves were analyzed using the Kaplan-Meier method for survival and Cox models for hazard ratios (HRs) with 95% confidence intervals (CIs). LF was preserved in 403 cases and not preserved in 177 cases. The 3- and 5-year survival rates were 70.9 and 52.7%, respectively, in the LF preservation group and 48.4 and 30.5%, respectively, in the no LF preservation group. Compared with the patients without LF preservation, patients with LF preservation had a significantly reduced risk of overall death (HR=0.63, 95% CI: 0.50-0.80). LF preservation positively affects the prognosis of patients with HSCC.

AB - The aims of the present study were to review the experience of different surgical reconstruction methods for hypopharyngeal squamous cell carcinoma (HSCC) and compared the survival of patients with and without laryngeal function (LF) preservation. The clinical characteristics of 580 patients were retrospectively obtained and analyzed. Survival curves were analyzed using the Kaplan-Meier method for survival and Cox models for hazard ratios (HRs) with 95% confidence intervals (CIs). LF was preserved in 403 cases and not preserved in 177 cases. The 3- and 5-year survival rates were 70.9 and 52.7%, respectively, in the LF preservation group and 48.4 and 30.5%, respectively, in the no LF preservation group. Compared with the patients without LF preservation, patients with LF preservation had a significantly reduced risk of overall death (HR=0.63, 95% CI: 0.50-0.80). LF preservation positively affects the prognosis of patients with HSCC.

KW - Combined modality therapy

KW - Function preservation

KW - Hypopharyngeal squamous cell carcinoma

KW - Laryngectomy

KW - Pharyngectomy

KW - Quality of life

KW - Survival

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U2 - 10.3892/or.2015.4313

DO - 10.3892/or.2015.4313

M3 - Review article

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AN - SCOPUS:84943808327

SN - 1021-335X

VL - 34

SP - 3196

EP - 3202

JO - Oncology reports

JF - Oncology reports

IS - 6

ER -

Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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