Overcoming antiangiogenic resistance

James C. Yao; Alexandria Phan

doi:10.1158/1078-0432.CCR-11-1219

Overcoming antiangiogenic resistance

James C. Yao, Alexandria Phan

GI Medical Oncology

Research output: Contribution to journal › Short survey › peer-review

15 Scopus citations

Abstract

The success of Drugs targeting angiogenesis is tempered by the transient duration of disease control and modest survival improvement. The very hypoxic stress produced by successful therapy may lead to upregulation of multiple pathways that promote angiogenesis and invasive behavior. Overcoming this evasive resistance may further improve outcome.

Original language	English (US)
Pages (from-to)	5217-5219
Number of pages	3
Journal	Clinical Cancer Research
Volume	17
Issue number	16
DOIs	https://doi.org/10.1158/1078-0432.CCR-11-1219
State	Published - Aug 15 2011

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1158/1078-0432.CCR-11-1219

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title = "Overcoming antiangiogenic resistance",

abstract = "The success of Drugs targeting angiogenesis is tempered by the transient duration of disease control and modest survival improvement. The very hypoxic stress produced by successful therapy may lead to upregulation of multiple pathways that promote angiogenesis and invasive behavior. Overcoming this evasive resistance may further improve outcome.",

author = "Yao, {James C.} and Alexandria Phan",

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AU - Yao, James C.

AU - Phan, Alexandria

PY - 2011/8/15

Y1 - 2011/8/15

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M3 - Short survey

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AN - SCOPUS:80051697787

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VL - 17

SP - 5217

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JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 16

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Overcoming antiangiogenic resistance

Abstract

ASJC Scopus subject areas

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