p53 and breast cancer

A. M. Thompson

doi:10.1016/0960-9776(93)90029-F

p53 and breast cancer

A. M. Thompson

Surgical Oncology

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The p53 gene is commonly abnormal in sporadic breast cancer. Loss of normal p53 tumour suppressor function has been implicated in up to 61% of breast cancers and mutated p53, which may behave as an oncogene, has been directly demonstrated in 15-46%. These events affecting p53 may occur early in breast carcinogenesis, but also correlate with poor prognostic features in invasive breast cancer. Abnormalities of the p53 gene are common and could be key events in the pathogenesis of breast cancer.

Original language	English (US)
Pages (from-to)	8-10
Number of pages	3
Journal	The Breast
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/0960-9776(93)90029-F
State	Published - Mar 1993

ASJC Scopus subject areas

Surgery

Access to Document

10.1016/0960-9776(93)90029-F

Cite this

@article{70e31a6bb7c346e1adc4fb285de227be,

title = "p53 and breast cancer",

abstract = "The p53 gene is commonly abnormal in sporadic breast cancer. Loss of normal p53 tumour suppressor function has been implicated in up to 61% of breast cancers and mutated p53, which may behave as an oncogene, has been directly demonstrated in 15-46%. These events affecting p53 may occur early in breast carcinogenesis, but also correlate with poor prognostic features in invasive breast cancer. Abnormalities of the p53 gene are common and could be key events in the pathogenesis of breast cancer.",

author = "Thompson, {A. M.}",

year = "1993",

month = mar,

doi = "10.1016/0960-9776(93)90029-F",

language = "English (US)",

volume = "2",

pages = "8--10",

journal = "The Breast",

issn = "0960-9776",

publisher = "Churchill Livingstone",

number = "1",

}

TY - JOUR

T1 - p53 and breast cancer

AU - Thompson, A. M.

PY - 1993/3

Y1 - 1993/3

N2 - The p53 gene is commonly abnormal in sporadic breast cancer. Loss of normal p53 tumour suppressor function has been implicated in up to 61% of breast cancers and mutated p53, which may behave as an oncogene, has been directly demonstrated in 15-46%. These events affecting p53 may occur early in breast carcinogenesis, but also correlate with poor prognostic features in invasive breast cancer. Abnormalities of the p53 gene are common and could be key events in the pathogenesis of breast cancer.

AB - The p53 gene is commonly abnormal in sporadic breast cancer. Loss of normal p53 tumour suppressor function has been implicated in up to 61% of breast cancers and mutated p53, which may behave as an oncogene, has been directly demonstrated in 15-46%. These events affecting p53 may occur early in breast carcinogenesis, but also correlate with poor prognostic features in invasive breast cancer. Abnormalities of the p53 gene are common and could be key events in the pathogenesis of breast cancer.

UR - http://www.scopus.com/inward/record.url?scp=0027276478&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027276478&partnerID=8YFLogxK

U2 - 10.1016/0960-9776(93)90029-F

DO - 10.1016/0960-9776(93)90029-F

M3 - Review article

AN - SCOPUS:0027276478

SN - 0960-9776

VL - 2

SP - 8

EP - 10

JO - The Breast

JF - The Breast

IS - 1

ER -

p53 and breast cancer

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this