Abstract
Paclitaxel is a novel anticancer drug that is being increasingly used to treat cancer of the breast and other organs. We describe a patient with metastatic breast cancer and liver dysfunction who had severe mucocutaneous toxicity after administration of a standard dose of paclitaxel. Another interesting finding in this patient was that the administration of paclitaxel led to a prompt resolution of parathyroid hormone-related protein (PTHrP)-mediated hypercalcemia, which had previously proven to be refractory to multiple conventional antihypercalcemic agents as well as anthracycline-containing chemotherapy combination. The need for definitive guidelines for paclitaxel administration in the setting of hepatic dysfunction and the potentially unique sensitivity of PTHrP-producing cells to paclitaxel are discussed.
Original language | English (US) |
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Pages (from-to) | 542-545 |
Number of pages | 4 |
Journal | Southern Medical Journal |
Volume | 89 |
Issue number | 5 |
DOIs | |
State | Published - May 1996 |
ASJC Scopus subject areas
- General Medicine