Pain-Induced Chromatin Modifications

Zhizhong Z. Pan; Chenghua Zhou; Yuqing Wu; Zhi Zhang; Youqing Cai

doi:10.1016/B978-0-12-814070-3.00006-5

Pain-Induced Chromatin Modifications

Zhizhong Z. Pan, Chenghua Zhou, Yuqing Wu, Zhi Zhang, Youqing Cai

Pain Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Recent years have seen a surging number of epigenetic studies and rapid progress in understanding of epigenetic mechanisms of gene regulation and their dysfunctions in the pathogenesis of neurological diseases such as chronic pain. As we gain increasing knowledge on the epigenetic machinery for transcriptional regulation of gene expression, all major processes of the epigenetic regulations identified so far have been implicated in the pathogenesis of pain, including histone acetylation and methylation, noncoding RNAs, and DNA methylation. This chapter reviews and summarizes research development and advances in these areas of pain epigenetics over the past decade, focusing on new findings in the last few years that address methylation and demethylation on histone proteins and DNA in pain-induced chromatin modifications.

Original language	English (US)
Title of host publication	Epigenetics of Chronic Pain
Publisher	Elsevier
Pages	111-124
Number of pages	14
ISBN (Electronic)	9780128140703
DOIs	https://doi.org/10.1016/B978-0-12-814070-3.00006-5
State	Published - Jan 1 2018

Keywords

Chromatin remodeling
DNA methylation
Epigenetics
Histone acetylation
Noncoding RNAs
Pain

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-814070-3.00006-5

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abstract = "Recent years have seen a surging number of epigenetic studies and rapid progress in understanding of epigenetic mechanisms of gene regulation and their dysfunctions in the pathogenesis of neurological diseases such as chronic pain. As we gain increasing knowledge on the epigenetic machinery for transcriptional regulation of gene expression, all major processes of the epigenetic regulations identified so far have been implicated in the pathogenesis of pain, including histone acetylation and methylation, noncoding RNAs, and DNA methylation. This chapter reviews and summarizes research development and advances in these areas of pain epigenetics over the past decade, focusing on new findings in the last few years that address methylation and demethylation on histone proteins and DNA in pain-induced chromatin modifications.",

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AU - Wu, Yuqing

AU - Zhang, Zhi

AU - Cai, Youqing

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AB - Recent years have seen a surging number of epigenetic studies and rapid progress in understanding of epigenetic mechanisms of gene regulation and their dysfunctions in the pathogenesis of neurological diseases such as chronic pain. As we gain increasing knowledge on the epigenetic machinery for transcriptional regulation of gene expression, all major processes of the epigenetic regulations identified so far have been implicated in the pathogenesis of pain, including histone acetylation and methylation, noncoding RNAs, and DNA methylation. This chapter reviews and summarizes research development and advances in these areas of pain epigenetics over the past decade, focusing on new findings in the last few years that address methylation and demethylation on histone proteins and DNA in pain-induced chromatin modifications.

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KW - DNA methylation

KW - Epigenetics

KW - Histone acetylation

KW - Noncoding RNAs

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Pain-Induced Chromatin Modifications

Abstract

Keywords

ASJC Scopus subject areas

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