TY - JOUR
T1 - Pancreatic cancer
T2 - Advances and challenges
AU - Halbrook, Christopher J.
AU - Lyssiotis, Costas A.
AU - Pasca di Magliano, Marina
AU - Maitra, Anirban
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/4/13
Y1 - 2023/4/13
N2 - Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant efforts have largely defined major genetic factors driving PDAC pathogenesis and progression. Pancreatic tumors are characterized by a complex microenvironment that orchestrates metabolic alterations and supports a milieu of interactions among various cell types within this niche. In this review, we highlight the foundational studies that have driven our understanding of these processes. We further discuss the recent technological advances that continue to expand our understanding of PDAC complexity. We posit that the clinical translation of these research endeavors will enhance the currently dismal survival rate of this recalcitrant disease.
AB - Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant efforts have largely defined major genetic factors driving PDAC pathogenesis and progression. Pancreatic tumors are characterized by a complex microenvironment that orchestrates metabolic alterations and supports a milieu of interactions among various cell types within this niche. In this review, we highlight the foundational studies that have driven our understanding of these processes. We further discuss the recent technological advances that continue to expand our understanding of PDAC complexity. We posit that the clinical translation of these research endeavors will enhance the currently dismal survival rate of this recalcitrant disease.
UR - http://www.scopus.com/inward/record.url?scp=85151541518&partnerID=8YFLogxK
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U2 - 10.1016/j.cell.2023.02.014
DO - 10.1016/j.cell.2023.02.014
M3 - Review article
C2 - 37059070
AN - SCOPUS:85151541518
SN - 0092-8674
VL - 186
SP - 1729
EP - 1754
JO - Cell
JF - Cell
IS - 8
ER -