Abstract
BACKGROUND Pancreatic paragangliomas (PPGL) are rare benign neuroendocrine neoplasms but malignancy can occur. PPGL are often misdiagnosed as pancreatic neuroendocrine tumor or pancreatic adenocarcinoma. CASE SUMMARY We reviewed 47 case reports of PPGL published in PubMed to date. Fifteen patients (15/47) with PPGL underwent endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). Only six (6/15) were correctly diagnosed as PPGL. All patients with PPGL underwent surgical resection except three (one patient surgery was aborted because of hypertensive crisis, two patients had metastasis or involvement of major vessels). Our patient remained on close surveillance as she was asymptomatic. CONCLUSION Accurate preoperative diagnosis of PPGL can be safely achieved by EUS-FNA with immunohistochemistry. Multidisciplinary team approach should be considered to bring the optimal results in the management of PPGL.
Original language | English (US) |
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Pages (from-to) | 6322-6331 |
Number of pages | 10 |
Journal | World journal of gastroenterology |
Volume | 27 |
Issue number | 37 |
DOIs | |
State | Published - Oct 7 2021 |
Keywords
- Case report
- Endoscopic ultrasound-guided fine needle aspiration
- GATA-3
- Immunohistochemistry
- Meta-iodobenzylguanidine scan
- Metanephrines
- Pancreatic paraganglioma
ASJC Scopus subject areas
- Gastroenterology