TY - JOUR
T1 - Paradoxical clinical effect of estrogen on breast cancer risk
T2 - A "new" biology of estrogen-induced apoptosis
AU - Jordan, V. Craig
AU - Ford, Leslie G.
PY - 2011/5
Y1 - 2011/5
N2 - Administration of estrogen replacement therapy (ERT) decreases the incidence of breast cancer, as shown in a double-blind, placebo-controlled randomized trial of the Women's Health Initiative (WHI) in 10,739 postmenopausal women with a prior hysterectomy. Although paradoxical because estrogen is recognized to stimulate breast cancer growth, laboratory data support a mechanism of estrogen-induced apoptosis under the correct environmental circumstances. Long-term antiestrogen treatment or estrogen deprivation causes the eventual development and evolution of antihormone resistance. Cell populations emerge with a vulnerability, as estrogen is no longer a survival signal but is an apoptotic trigger. The antitumor effect of ERT in estrogen-deprived postmenopausal women is consistent with laboratory models.
AB - Administration of estrogen replacement therapy (ERT) decreases the incidence of breast cancer, as shown in a double-blind, placebo-controlled randomized trial of the Women's Health Initiative (WHI) in 10,739 postmenopausal women with a prior hysterectomy. Although paradoxical because estrogen is recognized to stimulate breast cancer growth, laboratory data support a mechanism of estrogen-induced apoptosis under the correct environmental circumstances. Long-term antiestrogen treatment or estrogen deprivation causes the eventual development and evolution of antihormone resistance. Cell populations emerge with a vulnerability, as estrogen is no longer a survival signal but is an apoptotic trigger. The antitumor effect of ERT in estrogen-deprived postmenopausal women is consistent with laboratory models.
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U2 - 10.1158/1940-6207.CAPR-11-0185
DO - 10.1158/1940-6207.CAPR-11-0185
M3 - Review article
C2 - 21478501
AN - SCOPUS:79955870520
SN - 1940-6207
VL - 4
SP - 633
EP - 637
JO - Cancer Prevention Research
JF - Cancer Prevention Research
IS - 5
ER -