TY - JOUR
T1 - Paraganglioma of the endolarynx
T2 - A rare tumor in an uncommon location
AU - Smolarz, Joseph R.
AU - Hanna, Ehab Y.
AU - Williams, Michelle D.
AU - Kupferman, Michael E.
PY - 2010
Y1 - 2010
N2 - Background. Less than 80 reported cases of paragangliomas of the larynx are reported in the literature. A role for external beam radiation in this disease has not yet been explored. We present four cases of laryngeal paragangliomas treated at a large tertiary-care cancer center over a 35-year period. Methods. 124 cases of head and neck paragangliomas treated at a single institution from 1970 to 2005 were retrospectively studied. Patients with laryngeal paragangliomas were identified, and a comprehensive clinico-pathological review was undertaken. Results. We identified 4 patients with tumors arising in the larynx at the following subsites: supraglottis (2), glottis (1), and subglottis (1). Three patients were treated with surgery and one with definitive radiation alone. Conclusions. Laryngeal paragangliomas are rare tumors and are adequately treated with surgical resection. We also present one patient who was treated with radiation and had disease stabilization. Accurate histological classification is critical, and the role of genetic testing is emerging.
AB - Background. Less than 80 reported cases of paragangliomas of the larynx are reported in the literature. A role for external beam radiation in this disease has not yet been explored. We present four cases of laryngeal paragangliomas treated at a large tertiary-care cancer center over a 35-year period. Methods. 124 cases of head and neck paragangliomas treated at a single institution from 1970 to 2005 were retrospectively studied. Patients with laryngeal paragangliomas were identified, and a comprehensive clinico-pathological review was undertaken. Results. We identified 4 patients with tumors arising in the larynx at the following subsites: supraglottis (2), glottis (1), and subglottis (1). Three patients were treated with surgery and one with definitive radiation alone. Conclusions. Laryngeal paragangliomas are rare tumors and are adequately treated with surgical resection. We also present one patient who was treated with radiation and had disease stabilization. Accurate histological classification is critical, and the role of genetic testing is emerging.
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U2 - 10.1186/1758-3284-2-2
DO - 10.1186/1758-3284-2-2
M3 - Article
C2 - 20205783
AN - SCOPUS:77953406088
SN - 1758-3284
VL - 2
JO - Head and Neck Oncology
JF - Head and Neck Oncology
IS - 1
M1 - 2
ER -