TY - JOUR
T1 - Paragangliomas Arising in the Head and Neck
T2 - A Morphologic Review and Genetic Update
AU - Williams, Michelle D.
AU - Rich, Thereasa A.
N1 - Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2014
Y1 - 2014
N2 - Seventy percent of parasympathetic paragangliomas arise in the head and neck and are nonsecretory. Awareness of the differential diagnosis based on location, overlapping morphology, and immunohistochemical profiles aids in the correct diagnosis, particularly on limited tissue samples. Moreover, 30% to 40% of head and neck paragangliomas are known to be associated with hereditary syndromes, with the succinate dehydrogenase enzyme family comprising the most frequent association. The pathologist's role is becoming increasing critical for facilitating optimal patient care beyond the initial tissue diagnosis of paraganglioma to include screening and documenting potential hereditary tumors requiring further patient counseling and testing.
AB - Seventy percent of parasympathetic paragangliomas arise in the head and neck and are nonsecretory. Awareness of the differential diagnosis based on location, overlapping morphology, and immunohistochemical profiles aids in the correct diagnosis, particularly on limited tissue samples. Moreover, 30% to 40% of head and neck paragangliomas are known to be associated with hereditary syndromes, with the succinate dehydrogenase enzyme family comprising the most frequent association. The pathologist's role is becoming increasing critical for facilitating optimal patient care beyond the initial tissue diagnosis of paraganglioma to include screening and documenting potential hereditary tumors requiring further patient counseling and testing.
KW - Familial syndromes
KW - Head and neck neoplasms
KW - Morphology
KW - Paraganglioma
KW - SDHB immunohistochemistry
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U2 - 10.1016/j.path.2014.08.007
DO - 10.1016/j.path.2014.08.007
M3 - Review article
C2 - 26837554
AN - SCOPUS:84923257519
SN - 1875-9181
VL - 7
SP - 543
EP - 557
JO - Surgical Pathology Clinics
JF - Surgical Pathology Clinics
IS - 4
ER -