Participation of lymphoid cells in the withdrawal syndrome of opiate dependent rats

N. R. Pellis; N. E. Kletzly; P. M. Dougherty; J. Aronowski; N. Dafny

doi:10.1016/0024-3205(87)90124-X

Participation of lymphoid cells in the withdrawal syndrome of opiate dependent rats

N. R. Pellis, N. E. Kletzly, P. M. Dougherty, J. Aronowski, N. Dafny

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Treatment of rats with 500 Rads whole-body ionizing irradiation prior to chronic administration of morphine reduced the severity of the naloxone induced withdrawal signs. In contrast, adoptive transfer of 2-6 × 10⁸ lymphoid cells to irradiated rats prior to chronic morphine treatment completely restored the ability to manifest the withdrawal signs precipitated by naloxone. These observations offer the possibility that the immune system participates in opiate addiction.

Original language	English (US)
Pages (from-to)	1589-1593
Number of pages	5
Journal	Life Sciences
Volume	40
Issue number	16
DOIs	https://doi.org/10.1016/0024-3205(87)90124-X
State	Published - Apr 20 1987
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(87)90124-X

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abstract = "Treatment of rats with 500 Rads whole-body ionizing irradiation prior to chronic administration of morphine reduced the severity of the naloxone induced withdrawal signs. In contrast, adoptive transfer of 2-6 × 108 lymphoid cells to irradiated rats prior to chronic morphine treatment completely restored the ability to manifest the withdrawal signs precipitated by naloxone. These observations offer the possibility that the immune system participates in opiate addiction.",

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AU - Pellis, N. R.

AU - Kletzly, N. E.

AU - Dougherty, P. M.

AU - Aronowski, J.

AU - Dafny, N.

PY - 1987/4/20

Y1 - 1987/4/20

N2 - Treatment of rats with 500 Rads whole-body ionizing irradiation prior to chronic administration of morphine reduced the severity of the naloxone induced withdrawal signs. In contrast, adoptive transfer of 2-6 × 108 lymphoid cells to irradiated rats prior to chronic morphine treatment completely restored the ability to manifest the withdrawal signs precipitated by naloxone. These observations offer the possibility that the immune system participates in opiate addiction.

AB - Treatment of rats with 500 Rads whole-body ionizing irradiation prior to chronic administration of morphine reduced the severity of the naloxone induced withdrawal signs. In contrast, adoptive transfer of 2-6 × 108 lymphoid cells to irradiated rats prior to chronic morphine treatment completely restored the ability to manifest the withdrawal signs precipitated by naloxone. These observations offer the possibility that the immune system participates in opiate addiction.

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Participation of lymphoid cells in the withdrawal syndrome of opiate dependent rats

Abstract

ASJC Scopus subject areas

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