Pathological examination of sentinel lymph node in breast cancer: Potential problems and possible solutions

Syed A. Hoda; April Chiu; Erika Resetkova; Malini Harigopal; Rana S. Hoda; Michael P. Osborne

doi:10.1002/jemt.10179

Pathological examination of sentinel lymph node in breast cancer: Potential problems and possible solutions

Syed A. Hoda, April Chiu, Erika Resetkova, Malini Harigopal, Rana S. Hoda, Michael P. Osborne

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Sentinel lymph node (SLN) biopsy has emerged during the last few years as a viable option for staging the axilla in the treatment of breast carcinoma. This procedure can potentially identify patients who would be helped by full axillary lymph node dissection (the SLN-positive cases), and those who would not (the SLN-negative cases). Review of the literature confirms the promise of SLN; however, the possible problems in the pathological handling of SLN, including the microscopic misinterpretation of benign structures and "spurious" immunohistochemical staining, need wider recognition.

Original language	English (US)
Pages (from-to)	85-91
Number of pages	7
Journal	Microscopy Research and Technique
Volume	59
Issue number	2
DOIs	https://doi.org/10.1002/jemt.10179
State	Published - Oct 15 2002
Externally published	Yes

Keywords

Breast carcinoma
Lymph node
Metastatic disease
Micrometastatic disease
Sentinel lymph node

ASJC Scopus subject areas

Anatomy
Histology
Instrumentation
Medical Laboratory Technology

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abstract = "Sentinel lymph node (SLN) biopsy has emerged during the last few years as a viable option for staging the axilla in the treatment of breast carcinoma. This procedure can potentially identify patients who would be helped by full axillary lymph node dissection (the SLN-positive cases), and those who would not (the SLN-negative cases). Review of the literature confirms the promise of SLN; however, the possible problems in the pathological handling of SLN, including the microscopic misinterpretation of benign structures and {"}spurious{"} immunohistochemical staining, need wider recognition.",

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AU - Hoda, Syed A.

AU - Chiu, April

AU - Resetkova, Erika

AU - Harigopal, Malini

AU - Hoda, Rana S.

AU - Osborne, Michael P.

PY - 2002/10/15

Y1 - 2002/10/15

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AB - Sentinel lymph node (SLN) biopsy has emerged during the last few years as a viable option for staging the axilla in the treatment of breast carcinoma. This procedure can potentially identify patients who would be helped by full axillary lymph node dissection (the SLN-positive cases), and those who would not (the SLN-negative cases). Review of the literature confirms the promise of SLN; however, the possible problems in the pathological handling of SLN, including the microscopic misinterpretation of benign structures and "spurious" immunohistochemical staining, need wider recognition.

KW - Breast carcinoma

KW - Lymph node

KW - Metastatic disease

KW - Micrometastatic disease

KW - Sentinel lymph node

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Pathological examination of sentinel lymph node in breast cancer: Potential problems and possible solutions

Abstract

Keywords

ASJC Scopus subject areas

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