Pathologist-initiated reflex testing for biomarkers in non-small-cell lung cancer: expert consensus on the rationale and considerations for implementation

J. R. Gosney; L. Paz-Ares; P. Jänne; K. M. Kerr; N. B. Leighl; M. D. Lozano; U. Malapelle; T. Mok; B. S. Sheffield; A. Tufman; I. I. Wistuba; S. Peters

doi:10.1016/j.esmoop.2023.101587

Pathologist-initiated reflex testing for biomarkers in non-small-cell lung cancer: expert consensus on the rationale and considerations for implementation

J. R. Gosney, L. Paz-Ares, P. Jänne, K. M. Kerr, N. B. Leighl, M. D. Lozano, U. Malapelle, T. Mok, B. S. Sheffield, A. Tufman, I. I. Wistuba, S. Peters

Translational Molecular Pathology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Biomarker tests in lung cancer have been traditionally ordered by the treating oncologist upon confirmation of an appropriate pathological diagnosis. The delay this introduces prolongs yet further what is already a complex, multi-stage, pre-treatment pathway and delays the start of first-line systemic treatment, which is crucially informed by the results of such analysis. Reflex testing, in which the responsibility for testing for an agreed range of biomarkers lies with the pathologist, has been shown to standardise and expedite the process. Twelve experts discussed the rationale and considerations for implementing reflex testing as standard clinical practice.

Original language	English (US)
Article number	101587
Journal	ESMO Open
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/j.esmoop.2023.101587
State	Published - Aug 2023

Keywords

NSCLC
molecular pathology
non-small-cell lung cancer
predictive biomarkers
reflex testing
turnaround time

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.esmoop.2023.101587

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Gosney, J. R., Paz-Ares, L., Jänne, P., Kerr, K. M., Leighl, N. B., Lozano, M. D., Malapelle, U., Mok, T., Sheffield, B. S., Tufman, A., Wistuba, I. I., & Peters, S. (2023). Pathologist-initiated reflex testing for biomarkers in non-small-cell lung cancer: expert consensus on the rationale and considerations for implementation. ESMO Open, 8(4), Article 101587. https://doi.org/10.1016/j.esmoop.2023.101587

Gosney, JR, Paz-Ares, L, Jänne, P, Kerr, KM, Leighl, NB, Lozano, MD, Malapelle, U, Mok, T, Sheffield, BS, Tufman, A, Wistuba, II & Peters, S 2023, 'Pathologist-initiated reflex testing for biomarkers in non-small-cell lung cancer: expert consensus on the rationale and considerations for implementation', ESMO Open, vol. 8, no. 4, 101587. https://doi.org/10.1016/j.esmoop.2023.101587

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abstract = "Biomarker tests in lung cancer have been traditionally ordered by the treating oncologist upon confirmation of an appropriate pathological diagnosis. The delay this introduces prolongs yet further what is already a complex, multi-stage, pre-treatment pathway and delays the start of first-line systemic treatment, which is crucially informed by the results of such analysis. Reflex testing, in which the responsibility for testing for an agreed range of biomarkers lies with the pathologist, has been shown to standardise and expedite the process. Twelve experts discussed the rationale and considerations for implementing reflex testing as standard clinical practice.",

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AU - Lozano, M. D.

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Pathologist-initiated reflex testing for biomarkers in non-small-cell lung cancer: expert consensus on the rationale and considerations for implementation

Abstract

Keywords

ASJC Scopus subject areas

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