TY - JOUR
T1 - Patient and treatment factors associated with survival among adult glioblastoma patients
T2 - A USA population-based study from 2000-2010
AU - Pan, I. Wen
AU - Ferguson, Sherise D.
AU - Lam, Sandi
PY - 2015/10/1
Y1 - 2015/10/1
N2 - In this study, we utilized the USA surveillance, epidemiology, and end results (SEER) database to examine factors influencing survival of glioblastoma multiforme (GBM) patients. GBM is the most common primary malignant brain tumor in adults and despite advances in treatment, prognosis remains poor. Using the SEER database, we defined a cohort of adult patients for the years 2000-2009 with confirmed GBM and minimum follow-up of 12 months. A total of 14,675 patients with GBM met the inclusion criteria. Demographic, clinical, and treatment variables were examined. Death was the primary outcome. Median survival time was 11 months. Patients had increasingly longer survival over the decade span. We found, on multivariate analysis, that significantly worse survival was associated with age >75 years, male sex, unmarried status, and non-Hispanic Caucasian race/ethnicity. Patients in the Northeast had a significantly lower risk of mortality. Patients with tumors that were non-lateralized and >3 cm fared worse. Patients who did not receive adjuvant radiation also had worse outcomes. Gross total resection imparted a survival advantage for patients compared to biopsy or partial resection. Thus, this report adds to the growing body of literature supporting the positive role of maximal resection on patient survival.
AB - In this study, we utilized the USA surveillance, epidemiology, and end results (SEER) database to examine factors influencing survival of glioblastoma multiforme (GBM) patients. GBM is the most common primary malignant brain tumor in adults and despite advances in treatment, prognosis remains poor. Using the SEER database, we defined a cohort of adult patients for the years 2000-2009 with confirmed GBM and minimum follow-up of 12 months. A total of 14,675 patients with GBM met the inclusion criteria. Demographic, clinical, and treatment variables were examined. Death was the primary outcome. Median survival time was 11 months. Patients had increasingly longer survival over the decade span. We found, on multivariate analysis, that significantly worse survival was associated with age >75 years, male sex, unmarried status, and non-Hispanic Caucasian race/ethnicity. Patients in the Northeast had a significantly lower risk of mortality. Patients with tumors that were non-lateralized and >3 cm fared worse. Patients who did not receive adjuvant radiation also had worse outcomes. Gross total resection imparted a survival advantage for patients compared to biopsy or partial resection. Thus, this report adds to the growing body of literature supporting the positive role of maximal resection on patient survival.
KW - Extent of resection
KW - Glioblastoma
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=84941166446&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941166446&partnerID=8YFLogxK
U2 - 10.1016/j.jocn.2015.03.032
DO - 10.1016/j.jocn.2015.03.032
M3 - Article
C2 - 26122381
AN - SCOPUS:84941166446
SN - 0967-5868
VL - 22
SP - 1575
EP - 1581
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
IS - 10
M1 - 6046
ER -