TY - JOUR
T1 - Patient preferences regarding side effects of chemotherapy for ovarian cancer
T2 - Do they change over time?
AU - Sun, Charlotte C.
AU - Bodurka, Diane C.
AU - Donato, Michele L.
AU - Rubenstein, Edward B.
AU - Borden, Candice L.
AU - Basen-Engquist, Karen
AU - Munsell, Mark F.
AU - Kavanagh, John J.
AU - Gershenson, David M.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2002
Y1 - 2002
N2 - Objective. The goals of this study were to: (1) systematically evaluate patient preferences regarding side effects of high-dose chemotherapy with stem cell support for treatment of advanced ovarian cancer; and (2) assess whether patients' preferences changed over time. Methods. Forty patients with stage III or IV disease were enrolled in this study. Patients' preferences regarding 12 health states (side effects) were assessed using visual analogue scale (VAS) and time trade-off (TTO) methods during mobilization chemotherapy (T1) and 6-7 weeks later after high-dose chemotherapy and stem cell transplant (T2). Each assessment involved a 45-min interview conducted at the patient's bedside. Results. The three most preferred health states were no evidence of disease (NED), a chemotherapy with few or no side effects, and alopecia, while the least preferred health states were chemotherapy with multiple severe side effects, hepatotoxicity, and nausea and vomiting. These results were observed at both T1 and T2 using both preference assessment methods. Pancytopenia scores significantly increased from T1 to T2 using the VAS method (P < 0.05), but decreased using the TTO method. Conclusions. Chemotherapy-experienced women with ovarian cancer have consistent preferences for the best and worst health states associated with the side effects of chemotherapy. Patients are more averse to nausea and vomiting than many other symptoms. Women's perceptions of pancytopenia may be dependent upon the number of prior cycles of chemotherapy and site of care for anemia, thrombocytopenia, and febrile neutropenia.
AB - Objective. The goals of this study were to: (1) systematically evaluate patient preferences regarding side effects of high-dose chemotherapy with stem cell support for treatment of advanced ovarian cancer; and (2) assess whether patients' preferences changed over time. Methods. Forty patients with stage III or IV disease were enrolled in this study. Patients' preferences regarding 12 health states (side effects) were assessed using visual analogue scale (VAS) and time trade-off (TTO) methods during mobilization chemotherapy (T1) and 6-7 weeks later after high-dose chemotherapy and stem cell transplant (T2). Each assessment involved a 45-min interview conducted at the patient's bedside. Results. The three most preferred health states were no evidence of disease (NED), a chemotherapy with few or no side effects, and alopecia, while the least preferred health states were chemotherapy with multiple severe side effects, hepatotoxicity, and nausea and vomiting. These results were observed at both T1 and T2 using both preference assessment methods. Pancytopenia scores significantly increased from T1 to T2 using the VAS method (P < 0.05), but decreased using the TTO method. Conclusions. Chemotherapy-experienced women with ovarian cancer have consistent preferences for the best and worst health states associated with the side effects of chemotherapy. Patients are more averse to nausea and vomiting than many other symptoms. Women's perceptions of pancytopenia may be dependent upon the number of prior cycles of chemotherapy and site of care for anemia, thrombocytopenia, and febrile neutropenia.
KW - Chemotherapy side effects
KW - High-dose chemotherapy
KW - Ovarian cancer
KW - Patient preferences
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U2 - 10.1006/gyno.2002.6807
DO - 10.1006/gyno.2002.6807
M3 - Article
C2 - 12468352
AN - SCOPUS:0036929824
SN - 0090-8258
VL - 87
SP - 118
EP - 128
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 1
ER -