Pattern of neurobehavioral deficits associated with interferon alfa therapy for leukemia

M. A. Pavol; Christina A. Meyers; J. L. Rexer; A. D. Valentine; P. J. Mattis; M. Talpaz

doi:10.1212/WNL.45.5.947

Pattern of neurobehavioral deficits associated with interferon alfa therapy for leukemia

M. A. Pavol, Christina A. Meyers, J. L. Rexer, A. D. Valentine, P. J. Mattis, M. Talpaz

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157 Scopus citations

Abstract

We evaluated the neuropsychological and personality profiles of 25 patients with chronic myelogenous leukemia treated with interferon alfa (IFN-a). This group of persons performed well below expectation on tests of cognitive speed, verbal memory, and executive functions. Personality changes included depression, increased somatic concern, and stress reactions. A control group of leukemia patients not treated with IFN-a had significantly better cognitive speed and mood. The pattern of cognitive and personality changes in patients receiving IFN-a is highly suggestive of frontal-subcortical brain dysfunction.

Original language	English (US)
Pages (from-to)	947-950
Number of pages	4
Journal	Neurology
Volume	45
Issue number	5
DOIs	https://doi.org/10.1212/WNL.45.5.947
State	Published - May 1995

ASJC Scopus subject areas

Clinical Neurology

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AU - Mattis, P. J.

AU - Talpaz, M.

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AB - We evaluated the neuropsychological and personality profiles of 25 patients with chronic myelogenous leukemia treated with interferon alfa (IFN-a). This group of persons performed well below expectation on tests of cognitive speed, verbal memory, and executive functions. Personality changes included depression, increased somatic concern, and stress reactions. A control group of leukemia patients not treated with IFN-a had significantly better cognitive speed and mood. The pattern of cognitive and personality changes in patients receiving IFN-a is highly suggestive of frontal-subcortical brain dysfunction.

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Pattern of neurobehavioral deficits associated with interferon alfa therapy for leukemia

Abstract

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