TY - JOUR
T1 - Patterns of cerebral atrophy in HIV–1–infected individuals
T2 - Results of a quantitative MRI analysis
AU - Dal Pan, Gerald J.
AU - Mc Arthur, J. H.
AU - Aylward, E.
AU - Selnes, O. A.
AU - Nance-Sproson, T. E.
AU - Kumar, A. J.
AU - Mellits, E. D.
AU - Mc Arthur, J. C.
PY - 1992/11
Y1 - 1992/11
N2 - Article abstract Cerebral atrophy is a common radiologie manifestation of HIV dementia. To evaluate the relationship between cognitive impairment and cerebral atrophy, adjusting for age and immune status, we used standardized planimetry to measure the ventricle–brain ratio (VBR) and the bifrontal (BFR) and bicaudate (BCR) ratios, three measures of cerebral atrophy. We analyzed cranial MRIs of 23 HIV–1–seronegative controls (SN) and 116 HIV–1–infected individuals. Of the HIV–1–seropositive individuals, 37 had HIV dementia (DM group), 40 had neurologic or neuropsychological abnormalities insufficient for HIV dementia (NP+ group), and 39 were neurologically normal (NML group). We performed comparisons using analysis of covariance with correction for multiple comparisons. Both the VBR, a general measure of overall cerebral atrophy, and the BCR, a measure of atrophy in the region of the caudate nucleus, are significantly associated with dementia. The association is stronger for BCR enlargement than for VBR enlargement, suggesting that selective caudate region atrophy is associated with HIV dementia. These results indicate that overall cerebral atrophy and prominent caudate region atrophy are important radiographie features of HIV dementia.
AB - Article abstract Cerebral atrophy is a common radiologie manifestation of HIV dementia. To evaluate the relationship between cognitive impairment and cerebral atrophy, adjusting for age and immune status, we used standardized planimetry to measure the ventricle–brain ratio (VBR) and the bifrontal (BFR) and bicaudate (BCR) ratios, three measures of cerebral atrophy. We analyzed cranial MRIs of 23 HIV–1–seronegative controls (SN) and 116 HIV–1–infected individuals. Of the HIV–1–seropositive individuals, 37 had HIV dementia (DM group), 40 had neurologic or neuropsychological abnormalities insufficient for HIV dementia (NP+ group), and 39 were neurologically normal (NML group). We performed comparisons using analysis of covariance with correction for multiple comparisons. Both the VBR, a general measure of overall cerebral atrophy, and the BCR, a measure of atrophy in the region of the caudate nucleus, are significantly associated with dementia. The association is stronger for BCR enlargement than for VBR enlargement, suggesting that selective caudate region atrophy is associated with HIV dementia. These results indicate that overall cerebral atrophy and prominent caudate region atrophy are important radiographie features of HIV dementia.
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U2 - 10.1212/wnl.42.11.2125
DO - 10.1212/wnl.42.11.2125
M3 - Article
C2 - 1436522
AN - SCOPUS:0026473121
SN - 0028-3878
VL - 42
SP - 2125
EP - 2130
JO - Neurology
JF - Neurology
IS - 11
ER -