TY - JOUR
T1 - Pediatric Melanoma—Diagnosis, Management, and Anticipated Outcomes
AU - Aldrink, Jennifer H.
AU - Polites, Stephanie F.
AU - Austin, Mary
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/4
Y1 - 2021/4
N2 - Melanoma is the most common skin cancer in children, often presenting in an atypical fashion. The incidence of melanoma in children has been declining. The mainstay of therapy is surgical resection. Sentinel lymph node biopsy often is indicated to guide therapy and determine prognosis. Completion lymph node dissection is recommended in selective cases after positive sentinel lymph node biopsy. Those with advanced disease receive adjuvant systemic treatment. Because children are excluded from melanoma clinical trials, management is based on pediatric retrospective data and adult clinical trials. This review focuses on epidemiology, presentation, surgical management, adjuvant therapy, and outcomes of pediatric melanoma.
AB - Melanoma is the most common skin cancer in children, often presenting in an atypical fashion. The incidence of melanoma in children has been declining. The mainstay of therapy is surgical resection. Sentinel lymph node biopsy often is indicated to guide therapy and determine prognosis. Completion lymph node dissection is recommended in selective cases after positive sentinel lymph node biopsy. Those with advanced disease receive adjuvant systemic treatment. Because children are excluded from melanoma clinical trials, management is based on pediatric retrospective data and adult clinical trials. This review focuses on epidemiology, presentation, surgical management, adjuvant therapy, and outcomes of pediatric melanoma.
KW - Melanoma
KW - Pediatric
KW - Sentinel lymph node
KW - Skin lesion
UR - http://www.scopus.com/inward/record.url?scp=85100399512&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85100399512&partnerID=8YFLogxK
U2 - 10.1016/j.soc.2020.11.005
DO - 10.1016/j.soc.2020.11.005
M3 - Review article
C2 - 33706906
AN - SCOPUS:85100399512
SN - 1055-3207
VL - 30
SP - 373
EP - 388
JO - Surgical oncology clinics of North America
JF - Surgical oncology clinics of North America
IS - 2
ER -