TY - GEN
T1 - Performance evaluation of the low-cost high-sensitivity Rodent Research PET (RRPET) camera using Monte Carlo simulations
AU - Zhang, Yuxuan
AU - Wong, Wai Hoi
AU - Baghaei, Hossain
AU - Kim, Soonseok
AU - Li, Hongdi
AU - Liu, Jiguo
AU - Liu, Shitao
AU - Ramirez, Rocio
AU - Wang, Yu
AU - Xie, Shuping
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005
Y1 - 2005
N2 - BGO pentagonal blocks are used to build a solid detector cylinder for a Rodent Research PET (RRPET). With the PMT-quadrant-sharing design, this camera is low-cost and has higher sensitivity than commercial animal PET. The performance parameters of RRPET are obtained using Monte Carlo simulations by GATE, a newly developed toolkit based on GEANT4 for PET/SPECT. Two models of the RRPET system, one 30-slded-polygon geometry model and one 10-slded-polygon electronics model with different time-response constants, are used In the simulations to get the accurate results for both geometry-related and time-related parameters, Including the sensitivity, count rate and resolution. Several types of sources are simulated, Including a point source, a linear source, and several uniform sources simulating the mouse and the rat. The simulations give the Noise Equivalent Count Rate (NECR) curves with the maximum NECR of 2.2 Mcps @ 1.5 mCi for point source, 750 kcps @ 1.5 mCi for mouse-like source and 290 kcps @ 1.0 mCi for rat-like source; the sensitivity is 10.3%; the spatial resolution at the center of the Field of View (FOV) is 1.6 mm for an 18F source inside water phantom; the radial and tangential resolution at the edge of the FOV (10 cm) is 3.2 mm and 2.2 mm, respectively. Preliminary experiments showed a sensitivity of 8.4% to 10.2% (depending on electronics) and a resolution of 1.8 mm with a 22Na source. By comparing the simulation and experiment results, the resolution degradation from the mechanical misalignment and the block-decoding blurring is found to be 1.1 mm.
AB - BGO pentagonal blocks are used to build a solid detector cylinder for a Rodent Research PET (RRPET). With the PMT-quadrant-sharing design, this camera is low-cost and has higher sensitivity than commercial animal PET. The performance parameters of RRPET are obtained using Monte Carlo simulations by GATE, a newly developed toolkit based on GEANT4 for PET/SPECT. Two models of the RRPET system, one 30-slded-polygon geometry model and one 10-slded-polygon electronics model with different time-response constants, are used In the simulations to get the accurate results for both geometry-related and time-related parameters, Including the sensitivity, count rate and resolution. Several types of sources are simulated, Including a point source, a linear source, and several uniform sources simulating the mouse and the rat. The simulations give the Noise Equivalent Count Rate (NECR) curves with the maximum NECR of 2.2 Mcps @ 1.5 mCi for point source, 750 kcps @ 1.5 mCi for mouse-like source and 290 kcps @ 1.0 mCi for rat-like source; the sensitivity is 10.3%; the spatial resolution at the center of the Field of View (FOV) is 1.6 mm for an 18F source inside water phantom; the radial and tangential resolution at the edge of the FOV (10 cm) is 3.2 mm and 2.2 mm, respectively. Preliminary experiments showed a sensitivity of 8.4% to 10.2% (depending on electronics) and a resolution of 1.8 mm with a 22Na source. By comparing the simulation and experiment results, the resolution degradation from the mechanical misalignment and the block-decoding blurring is found to be 1.1 mm.
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U2 - 10.1109/NSSMIC.2005.1596851
DO - 10.1109/NSSMIC.2005.1596851
M3 - Conference contribution
AN - SCOPUS:33846643673
SN - 0780392213
SN - 9780780392212
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 2514
EP - 2518
BT - 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
T2 - Nuclear Science Symposium Conference Record, 2005 IEEE
Y2 - 23 October 2005 through 29 October 2005
ER -