TY - JOUR
T1 - Perioperative heart-type fatty acid binding protein levels in atrial fibrillation after cardiac surgery
AU - Rader, Florian
AU - Pujara, Akshat C.
AU - Pattakos, Gregory
AU - Rajeswaran, Jeevanantham
AU - Li, Liang
AU - Castel, Laurie
AU - Chung, Mina K.
AU - Marc Gillinov, A.
AU - Costantini, Otto
AU - Van Wagoner, David R.
AU - Blackstone, Eugene H.
N1 - Funding Information:
This publication, in part , was made possible by grant number RR024990 (to Dr Rader) from the National Center for Research Resources, a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research and the Physician Scientist Program of the Department of Medicine at Case Western Reserve University, MetroHealth Campus. Dr Pattakos is a National Heart, Lung and Blood Institute Clinical Research Scholar of the Cardiothoracic Surgical Trials Network, and his master of science in clinical research was funded by NIH grant 1U01HL088955-01 . Dr Chung was supported by NIH grant HL090620, and Dr Chung and Dr Van Wagoner were supported by the Fondation Leducq (European-North American Atrial Fibrillation Research Alliance, ENAFRA, 07/CVD-03).
PY - 2013/2
Y1 - 2013/2
N2 - Background: Postoperative atrial fibrillation (POAF) is common and associated with poor outcomes. Perioperative ischemia can alter arrhythmic substrate. Objective: To demonstrate an association between perioperative measurements of heart-type fatty acid binding protein (HT-FABP), a sensitive marker of ischemic myocardial injury. Methods: Blood samples from 63 inpatients undergoing coronary artery bypass surgery, valve surgery, or both were obtained before and up to 4 days after surgery. Continuous telemetry monitoring was used to detect POAF. Fifty-nine patients had at least 3 HT-FABP measurements. The relationship of enzyme-linked immunosorbent assay-measured HT-FABP with POAF was assessed by using joint logistic regression adjusted for age and surgery type. Results: Thirty-five patients (55%) developed POAF; these were, on average, older (69.3±10 years vs 60±11 years; P =.0019), with a higher prevalence of heart failure (43% vs 17%; P =.034), chronic obstructive lung disease (26% vs 4%; P =.017), preoperative calcium channel blocker use (29% vs 7%; P =.031), and more likely to undergo combined surgery (21% vs 11%, P =.049). The joint age- and coronary artery bypass surgery-adjusted model revealed that postoperative but not preoperative HT-FABP levels predicted POAF (coefficient 1.9±0.87; P =.03). Longer bypass time, prior infarction, and worse renal function were all associated with higher postoperative HT-FABP. Conclusions: A greater rise of HT-FABP is associated with atrial fibrillation after cardiac surgery, suggesting that ischemic myocardial damage is a contributing underlying mechanism. Interventions that decrease perioperative ischemic injury may also decrease the occurrence of POAF.
AB - Background: Postoperative atrial fibrillation (POAF) is common and associated with poor outcomes. Perioperative ischemia can alter arrhythmic substrate. Objective: To demonstrate an association between perioperative measurements of heart-type fatty acid binding protein (HT-FABP), a sensitive marker of ischemic myocardial injury. Methods: Blood samples from 63 inpatients undergoing coronary artery bypass surgery, valve surgery, or both were obtained before and up to 4 days after surgery. Continuous telemetry monitoring was used to detect POAF. Fifty-nine patients had at least 3 HT-FABP measurements. The relationship of enzyme-linked immunosorbent assay-measured HT-FABP with POAF was assessed by using joint logistic regression adjusted for age and surgery type. Results: Thirty-five patients (55%) developed POAF; these were, on average, older (69.3±10 years vs 60±11 years; P =.0019), with a higher prevalence of heart failure (43% vs 17%; P =.034), chronic obstructive lung disease (26% vs 4%; P =.017), preoperative calcium channel blocker use (29% vs 7%; P =.031), and more likely to undergo combined surgery (21% vs 11%, P =.049). The joint age- and coronary artery bypass surgery-adjusted model revealed that postoperative but not preoperative HT-FABP levels predicted POAF (coefficient 1.9±0.87; P =.03). Longer bypass time, prior infarction, and worse renal function were all associated with higher postoperative HT-FABP. Conclusions: A greater rise of HT-FABP is associated with atrial fibrillation after cardiac surgery, suggesting that ischemic myocardial damage is a contributing underlying mechanism. Interventions that decrease perioperative ischemic injury may also decrease the occurrence of POAF.
KW - Atrial fibrillation
KW - Biomarker
KW - CABG
KW - Ischemia
KW - Postoperative
KW - Valve surgery
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U2 - 10.1016/j.hrthm.2012.10.007
DO - 10.1016/j.hrthm.2012.10.007
M3 - Article
C2 - 23041578
AN - SCOPUS:84873602775
SN - 1547-5271
VL - 10
SP - 153
EP - 157
JO - Heart Rhythm
JF - Heart Rhythm
IS - 2
ER -