Perioperative opioids and colorectal cancer recurrence: A systematic review of the literature

Oscar Diaz-Cambronero, Guido Mazzinari, Juan P. Cata

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Aim: To summarize the literature on the long-term impact of perioperative opioids in colorectal cancer. Materials & methods: Combined results from two searching strategies in PubMed/MEDLINE (1950-2018), based on a PICO approach; P: Opioid influence on cancer-related long-term outcome in patient undergoing colorectal surgery; I: Opioid drugs administered in the perioperative period; C: Correlation between dose and/or type of opioid with long-term oncologic outcome; O: Disease-free survival and/or overall survival (OS). Results: Thirteen articles fulfilled the predetermined inclusion criteria. Due to the heterogeneity of the different studies, a quantitative meta-analysis to sum the evidence was deemed unfeasible. Conclusion: Our review indicates that there is no conclusive evidence to avoid the use of opioids with the goal of reducing the risk of recurrence in colorectal cancer.

Original languageEnglish (US)
Pages (from-to)353-361
Number of pages9
JournalPain management
Volume8
Issue number5
DOIs
StatePublished - Sep 2018

Keywords

  • colorectal cancer
  • opioids
  • recurrence-free survival

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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