TY - JOUR
T1 - Perioperative steroids in tonsillectomy using electrocautery and sharp dissection techniques
AU - Hanasono, Matthew M.
AU - Lalakea, M. Lauren
AU - Mikulec, Anthony A.
AU - Shepard, Kimberly G.
AU - Wellis, Vinit
AU - Messner, Anna H.
PY - 2004/8
Y1 - 2004/8
N2 - Objective: To determine the effect of preoperative dexamethasone sodium phosphate administration on post-tonsillectomy morbidity for electrocautery ("hot") and sharp ("cold") dissection techniques. Design: Prospective, randomized, double-blind study. Setting: University pediatric hospital and county teaching hospital. Subjects: A total of 219 children, aged 9 months to 12 years, undergoing tonsillectomy. Intervention: Participants who underwent tonsillectomy were randomly assigned to receive either intravenous dexamethasone sodium phosphate (1 mg/kg) or placebo. Outcome Measures: Pain scores, oral intake, and emesis on postoperative day (POD) 1. Results: A total of 106 subjects (62 undergoing hot and 44 cold tonsillectomies) received preoperative steroids, and 113 (56 hot and 57 cold tonsillectomies) received placebo. On POD 1, pain scores reported by patients (P = .02), parents (P = .002), and physicians (P<.001) were significantly lower in subjects receiving steroids than in those receiving placebo. Emesis was reduced from a mean of 2.1 (placebo group) to 1.2 episodes (steroid group) (P = .02). Oral intake improved from 24.5% of normal diet (placebo) to 31.7% (steroid group) (P = .004). When all 4 groups were compared (cold placebo, cold steroid, hot placebo, and hot steroid), pain scores reported by physicians and parents were significantly lower in the cold steroid group than in the other groups. Conclusions: Perioperative dexamethasone use reduces posttonsillectomy morbidity in pediatric patients in the early postoperative period after hot or cold tonsillectomy. The combination of steroid and cold dissection technique provided the greatest advantage in reducing posttonsillectomy subjective pain levels.
AB - Objective: To determine the effect of preoperative dexamethasone sodium phosphate administration on post-tonsillectomy morbidity for electrocautery ("hot") and sharp ("cold") dissection techniques. Design: Prospective, randomized, double-blind study. Setting: University pediatric hospital and county teaching hospital. Subjects: A total of 219 children, aged 9 months to 12 years, undergoing tonsillectomy. Intervention: Participants who underwent tonsillectomy were randomly assigned to receive either intravenous dexamethasone sodium phosphate (1 mg/kg) or placebo. Outcome Measures: Pain scores, oral intake, and emesis on postoperative day (POD) 1. Results: A total of 106 subjects (62 undergoing hot and 44 cold tonsillectomies) received preoperative steroids, and 113 (56 hot and 57 cold tonsillectomies) received placebo. On POD 1, pain scores reported by patients (P = .02), parents (P = .002), and physicians (P<.001) were significantly lower in subjects receiving steroids than in those receiving placebo. Emesis was reduced from a mean of 2.1 (placebo group) to 1.2 episodes (steroid group) (P = .02). Oral intake improved from 24.5% of normal diet (placebo) to 31.7% (steroid group) (P = .004). When all 4 groups were compared (cold placebo, cold steroid, hot placebo, and hot steroid), pain scores reported by physicians and parents were significantly lower in the cold steroid group than in the other groups. Conclusions: Perioperative dexamethasone use reduces posttonsillectomy morbidity in pediatric patients in the early postoperative period after hot or cold tonsillectomy. The combination of steroid and cold dissection technique provided the greatest advantage in reducing posttonsillectomy subjective pain levels.
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U2 - 10.1001/archotol.130.8.917
DO - 10.1001/archotol.130.8.917
M3 - Article
C2 - 15313860
AN - SCOPUS:3843072137
SN - 0886-4470
VL - 130
SP - 917
EP - 921
JO - Archives of Otolaryngology - Head and Neck Surgery
JF - Archives of Otolaryngology - Head and Neck Surgery
IS - 8
ER -