Periorbital Skin and Eyelids

The most common cancers in the United States arise in the skin, the human body’s largest organ. While biopsy is the standard for diagnosis of skin lesions, certain clinical and imaging features may assist radiologists, histopathologists, and referring clinicians in narrowing the differential diagnosis. The most common skin cancers originate in the epithelial surface and include basal cell carcinoma, followed by squamous cell carcinoma, melanoma, Merkel cell carcinoma, and sebaceous carcinoma. Less commonly occurring tumors of the skin surface and subcutaneous soft tissues include various sarcomas and desmoid tumors. Lymphoma may also involve the skin surface and can be primary or secondary to disseminated disease.