Peritoneal sarcomatosis in pediatric malignancies

Winston W. Huh; Nancy E. Fitzgerald; Anita Mahajan; Andrea Hayes-Jordan

doi:10.1002/pbc.24293

Peritoneal sarcomatosis in pediatric malignancies

Winston W. Huh, Nancy E. Fitzgerald, Anita Mahajan, Andrea Hayes-Jordan

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Peritoneal sarcomatosis (PSC) is defined as peritoneal involvement of multiple sarcomatous tumors. Desmoplastic small round cell tumors (DSRCT) and rhabdomyosarcomas are the most common pediatric PSC cases. PSC has been treated with chemotherapy and mainly palliative surgery, but long-term outcome has been poor. New imaging technologies have improved the evaluation of disease extent and patterns of peritoneal dissemination, and cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is being evaluated as a treatment option to prolong remission in pediatric patients. We will review the clinical characteristics, potential biologic mechanisms, radiographic characteristics, and potential therapies for pediatric PSC patients.

Original language	English (US)
Pages (from-to)	12-17
Number of pages	6
Journal	Pediatric Blood and Cancer
Volume	60
Issue number	1
DOIs	https://doi.org/10.1002/pbc.24293
State	Published - Jan 2013

Keywords

Childhood cancer
Intraperitoneal
Pediatric
Sarcoma
Sarcomatosis

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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title = "Peritoneal sarcomatosis in pediatric malignancies",

abstract = "Peritoneal sarcomatosis (PSC) is defined as peritoneal involvement of multiple sarcomatous tumors. Desmoplastic small round cell tumors (DSRCT) and rhabdomyosarcomas are the most common pediatric PSC cases. PSC has been treated with chemotherapy and mainly palliative surgery, but long-term outcome has been poor. New imaging technologies have improved the evaluation of disease extent and patterns of peritoneal dissemination, and cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is being evaluated as a treatment option to prolong remission in pediatric patients. We will review the clinical characteristics, potential biologic mechanisms, radiographic characteristics, and potential therapies for pediatric PSC patients.",

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AU - Huh, Winston W.

AU - Fitzgerald, Nancy E.

AU - Mahajan, Anita

AU - Hayes-Jordan, Andrea

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AB - Peritoneal sarcomatosis (PSC) is defined as peritoneal involvement of multiple sarcomatous tumors. Desmoplastic small round cell tumors (DSRCT) and rhabdomyosarcomas are the most common pediatric PSC cases. PSC has been treated with chemotherapy and mainly palliative surgery, but long-term outcome has been poor. New imaging technologies have improved the evaluation of disease extent and patterns of peritoneal dissemination, and cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is being evaluated as a treatment option to prolong remission in pediatric patients. We will review the clinical characteristics, potential biologic mechanisms, radiographic characteristics, and potential therapies for pediatric PSC patients.

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KW - Intraperitoneal

KW - Pediatric

KW - Sarcoma

KW - Sarcomatosis

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Peritoneal sarcomatosis in pediatric malignancies

Abstract

Keywords

ASJC Scopus subject areas

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