TY - JOUR
T1 - Personal history of cancer as a risk factor for second primary lung cancer
T2 - Implications for lung cancer screening
AU - Nofal, Sara
AU - Niu, Jiangong
AU - Resong, Paul
AU - Jin, Jeff
AU - Merriman, Kelly W.
AU - Le, Xiuning
AU - Katki, Hormuzd
AU - Heymach, John
AU - Antonoff, Mara B.
AU - Ostrin, Edwin
AU - Wu, Jia
AU - Zhang, Jianjun
AU - Toumazis, Iakovos
N1 - Publisher Copyright:
© 2024 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
PY - 2024/3
Y1 - 2024/3
N2 - Background: Personal history of cancer is an independent risk factor for lung cancer but is omitted from existing lung cancer screening eligibility criteria. In this study, we assess the lung cancer risk among cancer survivors and discuss potential implications for screening. Methods: This was a retrospective, secondary analysis of data from the Surveillance, Epidemiology and End Results (SEER) registry and the MD Anderson Cancer Center (MDACC). We estimated the standardized incidence ratios (SIRs) for lung cancer by site of first primary cancer using data from SEER. We assessed the lung cancer risk among head and neck cancer survivors from MDACC using cumulative incidence and compared the risk ratios (RR) by individuals' screening eligibility status. Results: Other than first primary lung cancer (SIR: 5.10, 95% CI: 5.01–5.18), cancer survivors in SEER with personal history of head and neck cancer (SIR: 3.71, 95% CI: 3.63–3.80) had the highest risk of developing second primary lung cancer, followed by bladder (SIR: 1.86, 95% CI: 1.81–1.90) and esophageal cancers (SIR: 1.78, 95% CI: 1.61–1.96). Head and neck cancer survivors had higher risk to develop lung cancer compared to the National Lung Screening Trial's subjects, (781 vs. 572 per 100,000 person-years, respectively). Head and neck cancer survivors ineligible for lung cancer screening seen at MDACC had significantly higher lung cancer risk than head and neck cancer survivors from SEER (RR: 1.9, p < 0.001). Conclusion: Personal history of cancer, primarily head and neck cancer, is an independent risk factor for lung cancer and may be considered as an eligibility criterion in future lung cancer screening recommendations.
AB - Background: Personal history of cancer is an independent risk factor for lung cancer but is omitted from existing lung cancer screening eligibility criteria. In this study, we assess the lung cancer risk among cancer survivors and discuss potential implications for screening. Methods: This was a retrospective, secondary analysis of data from the Surveillance, Epidemiology and End Results (SEER) registry and the MD Anderson Cancer Center (MDACC). We estimated the standardized incidence ratios (SIRs) for lung cancer by site of first primary cancer using data from SEER. We assessed the lung cancer risk among head and neck cancer survivors from MDACC using cumulative incidence and compared the risk ratios (RR) by individuals' screening eligibility status. Results: Other than first primary lung cancer (SIR: 5.10, 95% CI: 5.01–5.18), cancer survivors in SEER with personal history of head and neck cancer (SIR: 3.71, 95% CI: 3.63–3.80) had the highest risk of developing second primary lung cancer, followed by bladder (SIR: 1.86, 95% CI: 1.81–1.90) and esophageal cancers (SIR: 1.78, 95% CI: 1.61–1.96). Head and neck cancer survivors had higher risk to develop lung cancer compared to the National Lung Screening Trial's subjects, (781 vs. 572 per 100,000 person-years, respectively). Head and neck cancer survivors ineligible for lung cancer screening seen at MDACC had significantly higher lung cancer risk than head and neck cancer survivors from SEER (RR: 1.9, p < 0.001). Conclusion: Personal history of cancer, primarily head and neck cancer, is an independent risk factor for lung cancer and may be considered as an eligibility criterion in future lung cancer screening recommendations.
KW - cancer survivor
KW - head and neck cancer
KW - lung cancer screening
KW - personal history of cancer
KW - risk assessment
KW - Second primary lung cancer
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U2 - 10.1002/cam4.7069
DO - 10.1002/cam4.7069
M3 - Article
C2 - 38466021
AN - SCOPUS:85187464543
SN - 2045-7634
VL - 13
JO - Cancer medicine
JF - Cancer medicine
IS - 5
M1 - e7069
ER -