TY - JOUR
T1 - Personalized therapy of sarcomas
T2 - Integration of biomarkers for improved diagnosis, prognosis, and therapy selection
AU - Ludwig, Joseph A.
PY - 2008
Y1 - 2008
N2 - An improved understanding of cancer's molecular diversity at the genetic, proteomic, and epigenetic levels has made it evident that "sarcoma" comprises more than 50 different types, each as unique as, for example, breast carcinoma is from colon carcinoma. Sarcomas exhibit characteristic differences in cell of origin, disease site, likelihood and site of metastasis, growth propensity, and chemosensitivity. Additionally, as many as one third of sarcomas harbor specific chromosomal translocations that can be used to discriminate one subtype from another. Although biomarkers can be integrated into clinical practice to improve diagnostic accuracy and predict treatment response, a number of challenges hinder their widespread use. This review addresses the current use of biomarkers for clinical oncology, with special emphasis on diagnosis, staging, and grading. It also discusses types of biomarkers that are emerging to aid selection of therapy for patients with sarcoma. Finally, we consider practical factors that appear to limit biomarker integration into clinical practice.
AB - An improved understanding of cancer's molecular diversity at the genetic, proteomic, and epigenetic levels has made it evident that "sarcoma" comprises more than 50 different types, each as unique as, for example, breast carcinoma is from colon carcinoma. Sarcomas exhibit characteristic differences in cell of origin, disease site, likelihood and site of metastasis, growth propensity, and chemosensitivity. Additionally, as many as one third of sarcomas harbor specific chromosomal translocations that can be used to discriminate one subtype from another. Although biomarkers can be integrated into clinical practice to improve diagnostic accuracy and predict treatment response, a number of challenges hinder their widespread use. This review addresses the current use of biomarkers for clinical oncology, with special emphasis on diagnosis, staging, and grading. It also discusses types of biomarkers that are emerging to aid selection of therapy for patients with sarcoma. Finally, we consider practical factors that appear to limit biomarker integration into clinical practice.
UR - http://www.scopus.com/inward/record.url?scp=56149118853&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56149118853&partnerID=8YFLogxK
U2 - 10.1007/s11912-008-0051-6
DO - 10.1007/s11912-008-0051-6
M3 - Review article
C2 - 18778559
AN - SCOPUS:56149118853
SN - 1523-3790
VL - 10
SP - 329
EP - 337
JO - Current oncology reports
JF - Current oncology reports
IS - 4
ER -