PET imaging of hypoxia and apoptosis

Franklin C. Wong

doi:10.1016/B978-0-12-822960-6.00205-2

PET imaging of hypoxia and apoptosis

Franklin C. Wong

Nuclear Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Hypoxia and apoptosis are important biological processes that can be interrogated by molecular imaging and applied to study human diseases. This chapter reviews the capabilities and limitations of visualization of this biological processes. The basic mechanisms of imaging and the measurement parameters of hypoxia and apoptosis are delineated. The current state of art of PET imaging of hypoxia and apoptosis are presented. The requirements of these imaging technologies to serve as imaging biomarkers are also outlined. The perspective of hypoxia imaging and apoptosis imaging in the near future is also discussed.

Original language	English (US)
Title of host publication	Nuclear Medicine and Molecular Imaging
Subtitle of host publication	Volume 1-4
Publisher	Elsevier
Pages	549-556
Number of pages	8
Volume	3
ISBN (Electronic)	9780128229804
ISBN (Print)	9780128229606
DOIs	https://doi.org/10.1016/B978-0-12-822960-6.00205-2
State	Published - Jan 1 2022

Keywords

Annexin V
FAZA
FMISO
Imaging biomarker
Nitroimidazole derivatives
PET
SPECT

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/B978-0-12-822960-6.00205-2

Cite this

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AB - Hypoxia and apoptosis are important biological processes that can be interrogated by molecular imaging and applied to study human diseases. This chapter reviews the capabilities and limitations of visualization of this biological processes. The basic mechanisms of imaging and the measurement parameters of hypoxia and apoptosis are delineated. The current state of art of PET imaging of hypoxia and apoptosis are presented. The requirements of these imaging technologies to serve as imaging biomarkers are also outlined. The perspective of hypoxia imaging and apoptosis imaging in the near future is also discussed.

KW - Annexin V

KW - FAZA

KW - FMISO

KW - Imaging biomarker

KW - Nitroimidazole derivatives

KW - PET

KW - SPECT

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M3 - Chapter

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SN - 9780128229606

VL - 3

SP - 549

EP - 556

BT - Nuclear Medicine and Molecular Imaging

PB - Elsevier

ER -

PET imaging of hypoxia and apoptosis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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