TY - JOUR
T1 - Phantom Validation of DCE-MRI Magnitude and Phase-Based Vascular Input Function Measurements
AU - Foltz, Warren
AU - Driscoll, Brandon
AU - Laurence Lee, Sangjune
AU - Nayak, Krishna
AU - Nallapareddy, Naren
AU - Fatemi, Ali
AU - Ménard, Cynthia
AU - Coolens, Catherine
AU - Chung, Caroline
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Accurate, patient-specific measurement of arterial input functions (AIF) may improve model-based analysis of vascular permeability. This study investigated factors affecting AIF measurements from magnetic resonance imaging (MRI) magnitude (AIFMAGN) and phase (AIFPHA) signals, and compared them against computed tomography (CT) (AIFCT), under controlled conditions relevant to clinical protocols using a multimodality flow phantom. The flow phantom was applied at flip angles of 20° and 30°, flow rates (3-7.5 mL/s), and peak bolus concentrations (0.5-10 mM), for in-plane and through-plane flow. Spatial 3D-FLASH signal and variable flip angle T1 profiles were measured to investigate in-flow and radiofrequency-related biases, and magnitude- and phase-derived Gd-DTPA concentrations were compared. MRI AIF performance was tested against AIFCT via Pearson correlation analysis. AIFMAGN was sensitive to imaging orientation, spatial location, flip angle, and flow rate, and it grossly underestimated AIFCT peak concentrations. Conversion to Gd-DTPA concentration using T1 taken at the same orientation and flow rate as the dynamic contrast-enhanced acquisition improved AIFMAGN accuracy; yet, AIFMAGN metrics remained variable and significantly reduced from AIFCT at concentrations above 2.5 mM. AIFPHA performed equivalently within 1 mM to AIFCT across all tested conditions. AIFPHA, but not AIFMAGN, reported equivalent measurements to AIFCT across the range of tested conditions. AIFPHA showed superior robustness.
AB - Accurate, patient-specific measurement of arterial input functions (AIF) may improve model-based analysis of vascular permeability. This study investigated factors affecting AIF measurements from magnetic resonance imaging (MRI) magnitude (AIFMAGN) and phase (AIFPHA) signals, and compared them against computed tomography (CT) (AIFCT), under controlled conditions relevant to clinical protocols using a multimodality flow phantom. The flow phantom was applied at flip angles of 20° and 30°, flow rates (3-7.5 mL/s), and peak bolus concentrations (0.5-10 mM), for in-plane and through-plane flow. Spatial 3D-FLASH signal and variable flip angle T1 profiles were measured to investigate in-flow and radiofrequency-related biases, and magnitude- and phase-derived Gd-DTPA concentrations were compared. MRI AIF performance was tested against AIFCT via Pearson correlation analysis. AIFMAGN was sensitive to imaging orientation, spatial location, flip angle, and flow rate, and it grossly underestimated AIFCT peak concentrations. Conversion to Gd-DTPA concentration using T1 taken at the same orientation and flow rate as the dynamic contrast-enhanced acquisition improved AIFMAGN accuracy; yet, AIFMAGN metrics remained variable and significantly reduced from AIFCT at concentrations above 2.5 mM. AIFPHA performed equivalently within 1 mM to AIFCT across all tested conditions. AIFPHA, but not AIFMAGN, reported equivalent measurements to AIFCT across the range of tested conditions. AIFPHA showed superior robustness.
KW - MRI phase
KW - arterial input function (AIF)
KW - dynamic contrast-enhanced MRI (DCE-MRI)
KW - permeability
KW - phantom
KW - quantification
UR - http://www.scopus.com/inward/record.url?scp=85070704317&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070704317&partnerID=8YFLogxK
U2 - 10.18383/j.tom.2019.00001
DO - 10.18383/j.tom.2019.00001
M3 - Article
C2 - 30854445
SN - 2379-1381
VL - 5
SP - 77
EP - 89
JO - Tomography (Ann Arbor, Mich.)
JF - Tomography (Ann Arbor, Mich.)
IS - 1
ER -