TY - JOUR
T1 - Pharmacokinetics of cancer therapeutics and energy balance
T2 - the role of diet intake, energy expenditure, and body composition
AU - Purcell, Sarah A.
AU - Kok, Dieuwertje E.
AU - Ketterl, Tyler
AU - Garcia, Miriam B.
AU - Joffe, Lenat
AU - Brown, Justin C.
AU - Dieli-Conwright, Christina M.
AU - Williams, Grant R.
N1 - Publisher Copyright:
© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.
PY - 2023/5/4
Y1 - 2023/5/4
N2 - Energy balance accounts for an individual's energy intake, expenditure, and storage. Each aspect of energy balance has implications for the pharmacokinetics of cancer treatments and may impact an individual's drug exposure and subsequently its tolerance and efficacy. However, the integrated effects of diet, physical activity, and body composition on drug absorption, metabolism, distribution, and excretion are not yet fully understood. This review examines the existing literature on energy balance, specifically the role of dietary intake and nutritional status, physical activity and energy expenditure, and body composition on the pharmacokinetics of cancer therapeutics. As energy balance and pharmacokinetic factors can be influenced by age-related states of metabolism and comorbidities, this review also explores the age-related impact of body composition and physiologic changes on pharmacokinetics among pediatric and older adult populations with cancer.
AB - Energy balance accounts for an individual's energy intake, expenditure, and storage. Each aspect of energy balance has implications for the pharmacokinetics of cancer treatments and may impact an individual's drug exposure and subsequently its tolerance and efficacy. However, the integrated effects of diet, physical activity, and body composition on drug absorption, metabolism, distribution, and excretion are not yet fully understood. This review examines the existing literature on energy balance, specifically the role of dietary intake and nutritional status, physical activity and energy expenditure, and body composition on the pharmacokinetics of cancer therapeutics. As energy balance and pharmacokinetic factors can be influenced by age-related states of metabolism and comorbidities, this review also explores the age-related impact of body composition and physiologic changes on pharmacokinetics among pediatric and older adult populations with cancer.
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U2 - 10.1093/jncimonographs/lgad010
DO - 10.1093/jncimonographs/lgad010
M3 - Review article
C2 - 37139976
AN - SCOPUS:85159547770
SN - 1052-6773
VL - 2023
SP - 3
EP - 11
JO - Journal of the National Cancer Institute. Monographs
JF - Journal of the National Cancer Institute. Monographs
IS - 61
ER -