Pharmacologic inactivation of kinase suppressor of ras-1 abrogates ras-mediated pancreatic cancer

H. Rosie Xing; Carlos Cordon-Cardo; Xinzhu Deng; William Tong; Luis Campodonico; Zvi Fuks; Richard Kolesnick

doi:10.1038/nm927

Pharmacologic inactivation of kinase suppressor of ras-1 abrogates ras-mediated pancreatic cancer

H. Rosie Xing, Carlos Cordon-Cardo, Xinzhu Deng, William Tong, Luis Campodonico, Zvi Fuks, Richard Kolesnick

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Inhibition of the kinase suppressor of ras-1 (KSR1) gene by continuous infusion of phosphorothioate antisense oligonucleotides (ODNs) prevented growth of K-Ras-dependent human PANC-1 pancreatic and A549 non-small-cell lung carcinoma xenografts in nude mice, effected regression of established PANC-1 tumors and inhibited A549 lung metastases, all without apparent toxicity. These studies suggest KSR1 antisense ODNs as a treatment for Ras-dependent human malignancies, in particular pancreatic cancer, which lacks effective curative therapy.

Original language	English (US)
Pages (from-to)	1267-1268
Number of pages	2
Journal	Nature medicine
Volume	9
Issue number	10
DOIs	https://doi.org/10.1038/nm927
State	Published - Oct 2003

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Pharmacologic inactivation of kinase suppressor of ras-1 abrogates ras-mediated pancreatic cancer",

abstract = "Inhibition of the kinase suppressor of ras-1 (KSR1) gene by continuous infusion of phosphorothioate antisense oligonucleotides (ODNs) prevented growth of K-Ras-dependent human PANC-1 pancreatic and A549 non-small-cell lung carcinoma xenografts in nude mice, effected regression of established PANC-1 tumors and inhibited A549 lung metastases, all without apparent toxicity. These studies suggest KSR1 antisense ODNs as a treatment for Ras-dependent human malignancies, in particular pancreatic cancer, which lacks effective curative therapy.",

author = "Xing, {H. Rosie} and Carlos Cordon-Cardo and Xinzhu Deng and William Tong and Luis Campodonico and Zvi Fuks and Richard Kolesnick",

note = "Funding Information: These studies were supported by National Institutes of Health grants CA42385 (R.K.) and CA52462 (Z.F.).",

year = "2003",

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T1 - Pharmacologic inactivation of kinase suppressor of ras-1 abrogates ras-mediated pancreatic cancer

AU - Xing, H. Rosie

AU - Cordon-Cardo, Carlos

AU - Deng, Xinzhu

AU - Tong, William

AU - Campodonico, Luis

AU - Fuks, Zvi

AU - Kolesnick, Richard

N1 - Funding Information: These studies were supported by National Institutes of Health grants CA42385 (R.K.) and CA52462 (Z.F.).

PY - 2003/10

Y1 - 2003/10

N2 - Inhibition of the kinase suppressor of ras-1 (KSR1) gene by continuous infusion of phosphorothioate antisense oligonucleotides (ODNs) prevented growth of K-Ras-dependent human PANC-1 pancreatic and A549 non-small-cell lung carcinoma xenografts in nude mice, effected regression of established PANC-1 tumors and inhibited A549 lung metastases, all without apparent toxicity. These studies suggest KSR1 antisense ODNs as a treatment for Ras-dependent human malignancies, in particular pancreatic cancer, which lacks effective curative therapy.

AB - Inhibition of the kinase suppressor of ras-1 (KSR1) gene by continuous infusion of phosphorothioate antisense oligonucleotides (ODNs) prevented growth of K-Ras-dependent human PANC-1 pancreatic and A549 non-small-cell lung carcinoma xenografts in nude mice, effected regression of established PANC-1 tumors and inhibited A549 lung metastases, all without apparent toxicity. These studies suggest KSR1 antisense ODNs as a treatment for Ras-dependent human malignancies, in particular pancreatic cancer, which lacks effective curative therapy.

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Pharmacologic inactivation of kinase suppressor of ras-1 abrogates ras-mediated pancreatic cancer

Abstract

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