Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research

Bogdan Mateescu; Jennifer C. Jones; Roger P. Alexander; Eric Alsop; Ji Yeong An; Mohammad Asghari; Alex Boomgarden; Laura Bouchareychas; Alfonso Cayota; Hsueh Chia Chang; Al Charest; Daniel T. Chiu; Robert J. Coffey; Saumya Das; Peter De Hoff; Andrew deMello; Crislyn D'Souza-Schorey; David Elashoff; Kiarash R. Eliato; Jeffrey L. Franklin; David J. Galas; Mark B. Gerstein; Ionita H. Ghiran; David B. Go; Stephen Gould; Tristan R. Grogan; James N. Higginbotham; Florian Hladik; Tony Jun Huang; Xiaoye Huo; Elizabeth Hutchins; Dennis K. Jeppesen; Tijana Jovanovic-Talisman; Betty Y.S. Kim; Sung Kim; Kyoung Mee Kim; Yong Kim; Robert R. Kitchen; Vaughan Knouse; Emily L. LaPlante; Carlito B. Lebrilla; L. James Lee; Kathleen M. Lennon; Guoping Li; Feng Li; Tieyi Li; Tao Liu; Zirui Liu; Adam L. Maddox; Kyle McCarthy; Bessie Meechoovet; Nalin Maniya; Yingchao Meng; Aleksandar Milosavljevic; Byoung Hoon Min; Amber Morey; Martin Ng; John Nolan; Getulio P. De Oliveira Junior; Michael E. Paulaitis; Tuan Anh Phu; Robert L. Raffai; Eduardo Reátegui; Matthew E. Roth; David A. Routenberg; Joel Rozowsky; Joseph Rufo; Satyajyoti Senapati; Sigal Shachar; Himani Sharma; Anil K. Sood; Stavros Stavrakis; Alessandra Stürchler; Muneesh Tewari; Juan P. Tosar; Alexander K. Tucker-Schwartz; Andrey Turchinovich; Nedyalka Valkov; Kendall Van Keuren-Jensen; Kasey C. Vickers; Lucia Vojtech; Wyatt N. Vreeland; Ceming Wang; Kai Wang; Ze Yu Wang; Joshua A. Welsh; Kenneth W. Witwer; David T.W. Wong; Jianping Xia; Ya Hong Xie; Kaichun Yang; Mikołaj P. Zaborowski; Chenguang Zhang; Qin Zhang; Angela M. Zivkovic; Louise C. Laurent

doi:10.1016/j.isci.2022.104653

Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research

Bogdan Mateescu, Jennifer C. Jones, Roger P. Alexander, Eric Alsop, Ji Yeong An, Mohammad Asghari, Alex Boomgarden, Laura Bouchareychas, Alfonso Cayota, Hsueh Chia Chang, Al Charest, Daniel T. Chiu, Robert J. Coffey, Saumya Das, Peter De Hoff, Andrew deMello, Crislyn D'Souza-Schorey, David Elashoff, Kiarash R. Eliato, Jeffrey L. FranklinDavid J. Galas, Mark B. Gerstein, Ionita H. Ghiran, David B. Go, Stephen Gould, Tristan R. Grogan, James N. Higginbotham, Florian Hladik, Tony Jun Huang, Xiaoye Huo, Elizabeth Hutchins, Dennis K. Jeppesen, Tijana Jovanovic-Talisman, Betty Y.S. Kim, Sung Kim, Kyoung Mee Kim, Yong Kim, Robert R. Kitchen, Vaughan Knouse, Emily L. LaPlante, Carlito B. Lebrilla, L. James Lee, Kathleen M. Lennon, Guoping Li, Feng Li, Tieyi Li, Tao Liu, Zirui Liu, Adam L. Maddox, Kyle McCarthy, Bessie Meechoovet, Nalin Maniya, Yingchao Meng, Aleksandar Milosavljevic, Byoung Hoon Min, Amber Morey, Martin Ng, John Nolan, Getulio P. De Oliveira Junior, Michael E. Paulaitis, Tuan Anh Phu, Robert L. Raffai, Eduardo Reátegui, Matthew E. Roth, David A. Routenberg, Joel Rozowsky, Joseph Rufo, Satyajyoti Senapati, Sigal Shachar, Himani Sharma, Anil K. Sood, Stavros Stavrakis, Alessandra Stürchler, Muneesh Tewari, Juan P. Tosar, Alexander K. Tucker-Schwartz, Andrey Turchinovich, Nedyalka Valkov, Kendall Van Keuren-Jensen, Kasey C. Vickers, Lucia Vojtech, Wyatt N. Vreeland, Ceming Wang, Kai Wang, Ze Yu Wang, Joshua A. Welsh, Kenneth W. Witwer, David T.W. Wong, Jianping Xia, Ya Hong Xie, Kaichun Yang, Mikołaj P. Zaborowski, Chenguang Zhang, Qin Zhang, Angela M. Zivkovic, Louise C. Laurent

Research output: Contribution to journal › Review article › peer-review

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Abstract

The extracellular RNA communication consortium (ERCC) is an NIH-funded program aiming to promote the development of new technologies, resources, and knowledge about exRNAs and their carriers. After Phase 1 (2013–2018), Phase 2 of the program (ERCC2, 2019–2023) aims to fill critical gaps in knowledge and technology to enable rigorous and reproducible methods for separation and characterization of both bulk populations of exRNA carriers and single EVs. ERCC2 investigators are also developing new bioinformatic pipelines to promote data integration through the exRNA atlas database. ERCC2 has established several Working Groups (Resource Sharing, Reagent Development, Data Analysis and Coordination, Technology Development, nomenclature, and Scientific Outreach) to promote collaboration between ERCC2 members and the broader scientific community. We expect that ERCC2's current and future achievements will significantly improve our understanding of exRNA biology and the development of accurate and efficient exRNA-based diagnostic, prognostic, and theranostic biomarker assays.

Original language	English (US)
Article number	104653
Journal	iScience
Volume	25
Issue number	8
DOIs	https://doi.org/10.1016/j.isci.2022.104653
State	Published - Aug 19 2022

Keywords

Biochemistry
Biological sciences
Cell biology
Molecular biology

ASJC Scopus subject areas

General

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Mateescu, B., Jones, J. C., Alexander, R. P., Alsop, E., An, J. Y., Asghari, M., Boomgarden, A., Bouchareychas, L., Cayota, A., Chang, H. C., Charest, A., Chiu, D. T., Coffey, R. J., Das, S., De Hoff, P., deMello, A., D'Souza-Schorey, C., Elashoff, D., Eliato, K. R., ... Laurent, L. C. (2022). Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research. iScience, 25(8), Article 104653. https://doi.org/10.1016/j.isci.2022.104653

Mateescu, B, Jones, JC, Alexander, RP, Alsop, E, An, JY, Asghari, M, Boomgarden, A, Bouchareychas, L, Cayota, A, Chang, HC, Charest, A, Chiu, DT, Coffey, RJ, Das, S, De Hoff, P, deMello, A, D'Souza-Schorey, C, Elashoff, D, Eliato, KR, Franklin, JL, Galas, DJ, Gerstein, MB, Ghiran, IH, Go, DB, Gould, S, Grogan, TR, Higginbotham, JN, Hladik, F, Huang, TJ, Huo, X, Hutchins, E, Jeppesen, DK, Jovanovic-Talisman, T, Kim, BYS, Kim, S, Kim, KM, Kim, Y, Kitchen, RR, Knouse, V, LaPlante, EL, Lebrilla, CB, Lee, LJ, Lennon, KM, Li, G, Li, F, Li, T, Liu, T, Liu, Z, Maddox, AL, McCarthy, K, Meechoovet, B, Maniya, N, Meng, Y, Milosavljevic, A, Min, BH, Morey, A, Ng, M, Nolan, J, De Oliveira Junior, GP, Paulaitis, ME, Phu, TA, Raffai, RL, Reátegui, E, Roth, ME, Routenberg, DA, Rozowsky, J, Rufo, J, Senapati, S, Shachar, S, Sharma, H, Sood, AK, Stavrakis, S, Stürchler, A, Tewari, M, Tosar, JP, Tucker-Schwartz, AK, Turchinovich, A, Valkov, N, Van Keuren-Jensen, K, Vickers, KC, Vojtech, L, Vreeland, WN, Wang, C, Wang, K, Wang, ZY, Welsh, JA, Witwer, KW, Wong, DTW, Xia, J, Xie, YH, Yang, K, Zaborowski, MP, Zhang, C, Zhang, Q, Zivkovic, AM & Laurent, LC 2022, 'Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research', iScience, vol. 25, no. 8, 104653. https://doi.org/10.1016/j.isci.2022.104653

@article{0e87a2d804654727917d903598258db8,

title = "Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research",

abstract = "The extracellular RNA communication consortium (ERCC) is an NIH-funded program aiming to promote the development of new technologies, resources, and knowledge about exRNAs and their carriers. After Phase 1 (2013–2018), Phase 2 of the program (ERCC2, 2019–2023) aims to fill critical gaps in knowledge and technology to enable rigorous and reproducible methods for separation and characterization of both bulk populations of exRNA carriers and single EVs. ERCC2 investigators are also developing new bioinformatic pipelines to promote data integration through the exRNA atlas database. ERCC2 has established several Working Groups (Resource Sharing, Reagent Development, Data Analysis and Coordination, Technology Development, nomenclature, and Scientific Outreach) to promote collaboration between ERCC2 members and the broader scientific community. We expect that ERCC2's current and future achievements will significantly improve our understanding of exRNA biology and the development of accurate and efficient exRNA-based diagnostic, prognostic, and theranostic biomarker assays.",

keywords = "Biochemistry, Biological sciences, Cell biology, Molecular biology",

author = "Bogdan Mateescu and Jones, {Jennifer C.} and Alexander, {Roger P.} and Eric Alsop and An, {Ji Yeong} and Mohammad Asghari and Alex Boomgarden and Laura Bouchareychas and Alfonso Cayota and Chang, {Hsueh Chia} and Al Charest and Chiu, {Daniel T.} and Coffey, {Robert J.} and Saumya Das and {De Hoff}, Peter and Andrew deMello and Crislyn D'Souza-Schorey and David Elashoff and Eliato, {Kiarash R.} and Franklin, {Jeffrey L.} and Galas, {David J.} and Gerstein, {Mark B.} and Ghiran, {Ionita H.} and Go, {David B.} and Stephen Gould and Grogan, {Tristan R.} and Higginbotham, {James N.} and Florian Hladik and Huang, {Tony Jun} and Xiaoye Huo and Elizabeth Hutchins and Jeppesen, {Dennis K.} and Tijana Jovanovic-Talisman and Kim, {Betty Y.S.} and Sung Kim and Kim, {Kyoung Mee} and Yong Kim and Kitchen, {Robert R.} and Vaughan Knouse and LaPlante, {Emily L.} and Lebrilla, {Carlito B.} and Lee, {L. James} and Lennon, {Kathleen M.} and Guoping Li and Feng Li and Tieyi Li and Tao Liu and Zirui Liu and Maddox, {Adam L.} and Kyle McCarthy and Bessie Meechoovet and Nalin Maniya and Yingchao Meng and Aleksandar Milosavljevic and Min, {Byoung Hoon} and Amber Morey and Martin Ng and John Nolan and {De Oliveira Junior}, {Getulio P.} and Paulaitis, {Michael E.} and Phu, {Tuan Anh} and Raffai, {Robert L.} and Eduardo Re{\'a}tegui and Roth, {Matthew E.} and Routenberg, {David A.} and Joel Rozowsky and Joseph Rufo and Satyajyoti Senapati and Sigal Shachar and Himani Sharma and Sood, {Anil K.} and Stavros Stavrakis and Alessandra St{\"u}rchler and Muneesh Tewari and Tosar, {Juan P.} and Tucker-Schwartz, {Alexander K.} and Andrey Turchinovich and Nedyalka Valkov and {Van Keuren-Jensen}, Kendall and Vickers, {Kasey C.} and Lucia Vojtech and Vreeland, {Wyatt N.} and Ceming Wang and Kai Wang and Wang, {Ze Yu} and Welsh, {Joshua A.} and Witwer, {Kenneth W.} and Wong, {David T.W.} and Jianping Xia and Xie, {Ya Hong} and Kaichun Yang and Zaborowski, {Miko{\l}aj P.} and Chenguang Zhang and Qin Zhang and Zivkovic, {Angela M.} and Laurent, {Louise C.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2022",

month = aug,

day = "19",

doi = "10.1016/j.isci.2022.104653",

language = "English (US)",

volume = "25",

journal = "iScience",

issn = "2589-0042",

publisher = "Elsevier Inc.",

number = "8",

}

TY - JOUR

T1 - Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research

AU - Mateescu, Bogdan

AU - Jones, Jennifer C.

AU - Alexander, Roger P.

AU - Alsop, Eric

AU - An, Ji Yeong

AU - Asghari, Mohammad

AU - Boomgarden, Alex

AU - Bouchareychas, Laura

AU - Cayota, Alfonso

AU - Chang, Hsueh Chia

AU - Charest, Al

AU - Chiu, Daniel T.

AU - Coffey, Robert J.

AU - Das, Saumya

AU - De Hoff, Peter

AU - deMello, Andrew

AU - D'Souza-Schorey, Crislyn

AU - Elashoff, David

AU - Eliato, Kiarash R.

AU - Franklin, Jeffrey L.

AU - Galas, David J.

AU - Gerstein, Mark B.

AU - Ghiran, Ionita H.

AU - Go, David B.

AU - Gould, Stephen

AU - Grogan, Tristan R.

AU - Higginbotham, James N.

AU - Hladik, Florian

AU - Huang, Tony Jun

AU - Huo, Xiaoye

AU - Hutchins, Elizabeth

AU - Jeppesen, Dennis K.

AU - Jovanovic-Talisman, Tijana

AU - Kim, Betty Y.S.

AU - Kim, Sung

AU - Kim, Kyoung Mee

AU - Kim, Yong

AU - Kitchen, Robert R.

AU - Knouse, Vaughan

AU - LaPlante, Emily L.

AU - Lebrilla, Carlito B.

AU - Lee, L. James

AU - Lennon, Kathleen M.

AU - Li, Guoping

AU - Li, Feng

AU - Li, Tieyi

AU - Liu, Tao

AU - Liu, Zirui

AU - Maddox, Adam L.

AU - McCarthy, Kyle

AU - Meechoovet, Bessie

AU - Maniya, Nalin

AU - Meng, Yingchao

AU - Milosavljevic, Aleksandar

AU - Min, Byoung Hoon

AU - Morey, Amber

AU - Ng, Martin

AU - Nolan, John

AU - De Oliveira Junior, Getulio P.

AU - Paulaitis, Michael E.

AU - Phu, Tuan Anh

AU - Raffai, Robert L.

AU - Reátegui, Eduardo

AU - Roth, Matthew E.

AU - Routenberg, David A.

AU - Rozowsky, Joel

AU - Rufo, Joseph

AU - Senapati, Satyajyoti

AU - Shachar, Sigal

AU - Sharma, Himani

AU - Sood, Anil K.

AU - Stavrakis, Stavros

AU - Stürchler, Alessandra

AU - Tewari, Muneesh

AU - Tosar, Juan P.

AU - Tucker-Schwartz, Alexander K.

AU - Turchinovich, Andrey

AU - Valkov, Nedyalka

AU - Van Keuren-Jensen, Kendall

AU - Vickers, Kasey C.

AU - Vojtech, Lucia

AU - Vreeland, Wyatt N.

AU - Wang, Ceming

AU - Wang, Kai

AU - Wang, Ze Yu

AU - Welsh, Joshua A.

AU - Witwer, Kenneth W.

AU - Wong, David T.W.

AU - Xia, Jianping

AU - Xie, Ya Hong

AU - Yang, Kaichun

AU - Zaborowski, Mikołaj P.

AU - Zhang, Chenguang

AU - Zhang, Qin

AU - Zivkovic, Angela M.

AU - Laurent, Louise C.

PY - 2022/8/19

Y1 - 2022/8/19

N2 - The extracellular RNA communication consortium (ERCC) is an NIH-funded program aiming to promote the development of new technologies, resources, and knowledge about exRNAs and their carriers. After Phase 1 (2013–2018), Phase 2 of the program (ERCC2, 2019–2023) aims to fill critical gaps in knowledge and technology to enable rigorous and reproducible methods for separation and characterization of both bulk populations of exRNA carriers and single EVs. ERCC2 investigators are also developing new bioinformatic pipelines to promote data integration through the exRNA atlas database. ERCC2 has established several Working Groups (Resource Sharing, Reagent Development, Data Analysis and Coordination, Technology Development, nomenclature, and Scientific Outreach) to promote collaboration between ERCC2 members and the broader scientific community. We expect that ERCC2's current and future achievements will significantly improve our understanding of exRNA biology and the development of accurate and efficient exRNA-based diagnostic, prognostic, and theranostic biomarker assays.

AB - The extracellular RNA communication consortium (ERCC) is an NIH-funded program aiming to promote the development of new technologies, resources, and knowledge about exRNAs and their carriers. After Phase 1 (2013–2018), Phase 2 of the program (ERCC2, 2019–2023) aims to fill critical gaps in knowledge and technology to enable rigorous and reproducible methods for separation and characterization of both bulk populations of exRNA carriers and single EVs. ERCC2 investigators are also developing new bioinformatic pipelines to promote data integration through the exRNA atlas database. ERCC2 has established several Working Groups (Resource Sharing, Reagent Development, Data Analysis and Coordination, Technology Development, nomenclature, and Scientific Outreach) to promote collaboration between ERCC2 members and the broader scientific community. We expect that ERCC2's current and future achievements will significantly improve our understanding of exRNA biology and the development of accurate and efficient exRNA-based diagnostic, prognostic, and theranostic biomarker assays.

KW - Biochemistry

KW - Biological sciences

KW - Cell biology

KW - Molecular biology

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UR - http://www.scopus.com/inward/citedby.url?scp=85138548383&partnerID=8YFLogxK

U2 - 10.1016/j.isci.2022.104653

DO - 10.1016/j.isci.2022.104653

M3 - Review article

C2 - 35958027

AN - SCOPUS:85138548383

SN - 2589-0042

VL - 25

JO - iScience

JF - iScience

IS - 8

M1 - 104653

ER -

Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research

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