Phase II study of tiazofurin (NSC 286193) in the treatment of advanced small cell bronchogenic carcinoma

Paul Y. Holoye; David T. Carr; Hari M. Dhingra; Bonnie S. Glisson; Jin S. Lee; William K. Murphy; Theera Umsawasdi; Diane Jeffries

doi:10.1007/BF00175401

Phase II study of tiazofurin (NSC 286193) in the treatment of advanced small cell bronchogenic carcinoma

Paul Y. Holoye, David T. Carr, Hari M. Dhingra, Bonnie S. Glisson, Jin S. Lee, William K. Murphy, Theera Umsawasdi, Diane Jeffries

Thoracic Head & Neck Medical Oncology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Fourteen evaluable patients with small cell bronchogenic carcinoma received tiazofurin, an inhibitor of inosine monophosphate dehydrogenase, that progressed after one combination chemotherapy. No objective remission was observed at the dosage of 800 mg/m² for 5 consecutive days. Toxicity was moderate.

Original language	English (US)
Pages (from-to)	217-218
Number of pages	2
Journal	Investigational New Drugs
Volume	6
Issue number	3
DOIs	https://doi.org/10.1007/BF00175401
State	Published - Sep 1988

Keywords

small cell bronchogenic carcinoma
tiazofurin

ASJC Scopus subject areas

Oncology
Pharmacology
Pharmacology (medical)

Access to Document

10.1007/BF00175401

Cite this

@article{4c6ca64b73744eb4adf00babc966041e,

title = "Phase II study of tiazofurin (NSC 286193) in the treatment of advanced small cell bronchogenic carcinoma",

abstract = "Fourteen evaluable patients with small cell bronchogenic carcinoma received tiazofurin, an inhibitor of inosine monophosphate dehydrogenase, that progressed after one combination chemotherapy. No objective remission was observed at the dosage of 800 mg/m2 for 5 consecutive days. Toxicity was moderate.",

keywords = "small cell bronchogenic carcinoma, tiazofurin",

author = "Holoye, {Paul Y.} and Carr, {David T.} and Dhingra, {Hari M.} and Glisson, {Bonnie S.} and Lee, {Jin S.} and Murphy, {William K.} and Theera Umsawasdi and Diane Jeffries",

year = "1988",

month = sep,

doi = "10.1007/BF00175401",

language = "English (US)",

volume = "6",

pages = "217--218",

journal = "Investigational New Drugs",

issn = "0167-6997",

publisher = "Kluwer Academic Publishers",

number = "3",

}

TY - JOUR

T1 - Phase II study of tiazofurin (NSC 286193) in the treatment of advanced small cell bronchogenic carcinoma

AU - Holoye, Paul Y.

AU - Carr, David T.

AU - Dhingra, Hari M.

AU - Glisson, Bonnie S.

AU - Lee, Jin S.

AU - Murphy, William K.

AU - Umsawasdi, Theera

AU - Jeffries, Diane

PY - 1988/9

Y1 - 1988/9

N2 - Fourteen evaluable patients with small cell bronchogenic carcinoma received tiazofurin, an inhibitor of inosine monophosphate dehydrogenase, that progressed after one combination chemotherapy. No objective remission was observed at the dosage of 800 mg/m2 for 5 consecutive days. Toxicity was moderate.

AB - Fourteen evaluable patients with small cell bronchogenic carcinoma received tiazofurin, an inhibitor of inosine monophosphate dehydrogenase, that progressed after one combination chemotherapy. No objective remission was observed at the dosage of 800 mg/m2 for 5 consecutive days. Toxicity was moderate.

KW - small cell bronchogenic carcinoma

KW - tiazofurin

UR - http://www.scopus.com/inward/record.url?scp=0023792851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023792851&partnerID=8YFLogxK

U2 - 10.1007/BF00175401

DO - 10.1007/BF00175401

M3 - Article

C2 - 2847992

AN - SCOPUS:0023792851

SN - 0167-6997

VL - 6

SP - 217

EP - 218

JO - Investigational New Drugs

JF - Investigational New Drugs

IS - 3

ER -

Phase II study of tiazofurin (NSC 286193) in the treatment of advanced small cell bronchogenic carcinoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this