TY - JOUR
T1 - Phase II trial of fludarabine phosphate in lymphoma
T2 - An effective new agent in low-grade lymphoma
AU - Redman, John R.
AU - Cabanillas, Fernando
AU - Velasquez, William S.
AU - McLaughlin, Peter
AU - Hagemeister, Fredrick B.
AU - Swan, Forrest
AU - Rodriguez, Maria A.
AU - Plunkett, William K.
AU - Keating, Michael J.
PY - 1992
Y1 - 1992
N2 - Purpose: In a phase II trial we investigated fludarabine phosphate (FAMP) as therapy for patients with relapsed lymphoma to determine its effectiveness and toxicity in this disease. Patients and Methods: The 67 assessable patients had a median age of 56 years and had received a median of three chemotherapy regimens before treatment with FAMP. The starting dose was 25 mg/m2 administered intravenously over 30 minutes daily for 5 days every 3 to 4 weeks. Results: High response rates were observed for follicular small cleaved-cell lymphoma (FSCCL) (62%), follicular mixed small- and large-cell lymphoma (80%), and follicular large-cell lymphoma (FLCL) (100%). Responses also occurred in small lymphocytic lymphoma (SLL) (33%), transformed lymphoma (33%), mycosis fungoides (40%), and Hodgkin's disease (25%). No responses were observed in other intermediate- or high-grade lymphomas (N = 20). Overall, there were five patients with a complete response, 23 patients with a partial response, and an overall response rate of 37%. Toxicity was primarily hematologic and infectious. No significant gastrointestinal, hepatic, renal, or neurologic toxicity occurred. Conclusions: We conclude that FAMP has major activity in follicular hymphoma. Fundamental research is needed to understand this differential efficacy in low-grade lymphoma yet lack of efficacy in intermediate-and high-grade lymphoma. Clinical investigations should be done using FAMP in varying dose schedules and in combination regimens.
AB - Purpose: In a phase II trial we investigated fludarabine phosphate (FAMP) as therapy for patients with relapsed lymphoma to determine its effectiveness and toxicity in this disease. Patients and Methods: The 67 assessable patients had a median age of 56 years and had received a median of three chemotherapy regimens before treatment with FAMP. The starting dose was 25 mg/m2 administered intravenously over 30 minutes daily for 5 days every 3 to 4 weeks. Results: High response rates were observed for follicular small cleaved-cell lymphoma (FSCCL) (62%), follicular mixed small- and large-cell lymphoma (80%), and follicular large-cell lymphoma (FLCL) (100%). Responses also occurred in small lymphocytic lymphoma (SLL) (33%), transformed lymphoma (33%), mycosis fungoides (40%), and Hodgkin's disease (25%). No responses were observed in other intermediate- or high-grade lymphomas (N = 20). Overall, there were five patients with a complete response, 23 patients with a partial response, and an overall response rate of 37%. Toxicity was primarily hematologic and infectious. No significant gastrointestinal, hepatic, renal, or neurologic toxicity occurred. Conclusions: We conclude that FAMP has major activity in follicular hymphoma. Fundamental research is needed to understand this differential efficacy in low-grade lymphoma yet lack of efficacy in intermediate-and high-grade lymphoma. Clinical investigations should be done using FAMP in varying dose schedules and in combination regimens.
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U2 - 10.1200/JCO.1992.10.5.790
DO - 10.1200/JCO.1992.10.5.790
M3 - Article
C2 - 1373760
AN - SCOPUS:0026777233
SN - 0732-183X
VL - 10
SP - 790
EP - 794
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 5
ER -