TY - JOUR
T1 - Phase I/II randomized bilateral half-head comparison of topical bexarotene 1% gel for alopecia areata
AU - Talpur, Rakhshandra
AU - Vu, Jenny
AU - Bassett, Roland
AU - Stevens, Victor
AU - Duvic, Madeleine
PY - 2009/10
Y1 - 2009/10
N2 - Background: Alopecia areata, hair loss caused by perifollicular T-cell infiltrates, is refractory to therapy. Bexarotene, a retinoid X receptor is a selective retinoid, induces T-cell apoptosis. Objective: We sought to determine the safety, including the dose-limiting toxicities with adverse events, and efficacy, ie, response rate, of bexarotene in alopecia areata. Methods: We conducted a phase I/II randomized, half-head trial of 1% bexarotene gel applied twice daily for 6 months. Results: In all, 42 patients (11 male and 31 female) with alopecia totalis (n = 3), alopecia universalis (n = 5), or alopecia areata (n = 34) applied 1% bexarotene gel for 24 weeks. Five of 42 (12%) had 50% or more partial hair regrowth on the treated side, and 6 of 42 (14%) on both sides including 3 complete responders. In all, 31 patients had mild irritation; 4 had grade-3 irritation. Limitations: This design cannot differentiate between drug-induced and spontaneous regrowth. Conclusion: Topical bexarotene 1% application is well tolerated and possibly effective. A randomized placebo-controlled trial should be conducted.
AB - Background: Alopecia areata, hair loss caused by perifollicular T-cell infiltrates, is refractory to therapy. Bexarotene, a retinoid X receptor is a selective retinoid, induces T-cell apoptosis. Objective: We sought to determine the safety, including the dose-limiting toxicities with adverse events, and efficacy, ie, response rate, of bexarotene in alopecia areata. Methods: We conducted a phase I/II randomized, half-head trial of 1% bexarotene gel applied twice daily for 6 months. Results: In all, 42 patients (11 male and 31 female) with alopecia totalis (n = 3), alopecia universalis (n = 5), or alopecia areata (n = 34) applied 1% bexarotene gel for 24 weeks. Five of 42 (12%) had 50% or more partial hair regrowth on the treated side, and 6 of 42 (14%) on both sides including 3 complete responders. In all, 31 patients had mild irritation; 4 had grade-3 irritation. Limitations: This design cannot differentiate between drug-induced and spontaneous regrowth. Conclusion: Topical bexarotene 1% application is well tolerated and possibly effective. A randomized placebo-controlled trial should be conducted.
KW - alopecia areata
KW - alopecia totalis
KW - alopecia universalis
KW - bexarotene gel
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U2 - 10.1016/j.jaad.2009.02.037
DO - 10.1016/j.jaad.2009.02.037
M3 - Article
C2 - 19682769
AN - SCOPUS:69949177517
SN - 0190-9622
VL - 61
SP - 592.e1-592.e9
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 4
ER -