TY - GEN
T1 - Phenomenology of optical scattering from plasmonic aggregates for application to biological imaging and clinical therapeutics
AU - Travis, Kort
AU - Aaron, Jesse
AU - Harrison, Nathan
AU - Sokolov, Konstantin
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - Near-field coupling between plasmonic resonant nanoparticles and the associated shifts in scattering spectra enables the accomplishment of unprecedented observation of the co-localization dynamics of in-situ biomolecules on nanometer length-scales. We have recently shown that resonant nanoparticles conjugated to antibodies for cell-surface receptors provide a sensitive probe allowing the unambiguous resolution of not only the time sequence, but also the details of the intracellular pathway, for receptor-mediated endocytosis in live cells. In terms of general principles, the classical electrodynamics determining the scattering cross-section for nanoparticle aggregates is straightforward. However, the specifics of the angular dependence of the differential cross-section at a single wavelength, the wavelength dependence of this cross-section, and the correct implementation and interpretation of statistical averages of cross-section properties over an ensemble of aggregate morphologies are generally quite complicated, and in fact are often misinterpreted in the literature. Despite this complexity, we have constructed a set of few-parameter formulae describing optical scattering from nanoparticle aggregates by judicious combination of experimental results with extensive, near-exact simulation using the T-matrix technique. These phenomenological results facilitate the practical use of nanoparticle aggregates for biological measurement and clinical therapeutic applications.
AB - Near-field coupling between plasmonic resonant nanoparticles and the associated shifts in scattering spectra enables the accomplishment of unprecedented observation of the co-localization dynamics of in-situ biomolecules on nanometer length-scales. We have recently shown that resonant nanoparticles conjugated to antibodies for cell-surface receptors provide a sensitive probe allowing the unambiguous resolution of not only the time sequence, but also the details of the intracellular pathway, for receptor-mediated endocytosis in live cells. In terms of general principles, the classical electrodynamics determining the scattering cross-section for nanoparticle aggregates is straightforward. However, the specifics of the angular dependence of the differential cross-section at a single wavelength, the wavelength dependence of this cross-section, and the correct implementation and interpretation of statistical averages of cross-section properties over an ensemble of aggregate morphologies are generally quite complicated, and in fact are often misinterpreted in the literature. Despite this complexity, we have constructed a set of few-parameter formulae describing optical scattering from nanoparticle aggregates by judicious combination of experimental results with extensive, near-exact simulation using the T-matrix technique. These phenomenological results facilitate the practical use of nanoparticle aggregates for biological measurement and clinical therapeutic applications.
KW - Biomolecular labeling
KW - Nanoparticle aggregate
KW - Plasmonic resonance
UR - http://www.scopus.com/inward/record.url?scp=42149190592&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42149190592&partnerID=8YFLogxK
U2 - 10.1117/12.763869
DO - 10.1117/12.763869
M3 - Conference contribution
AN - SCOPUS:42149190592
SN - 9780819470447
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Plasmonics in Biology and Medicine V
T2 - Plasmonics in Biology and Medicine V
Y2 - 21 January 2008 through 22 January 2008
ER -