Phenyl N-t-butylnitrone, a reactive oxygen species scavenger, reduces zymosan-induced visceral pain in rats

Jigong Wang; Victoria Cochran; Salahadin Abdi; Jin Mo Chung; Kyungsoon Chung; Hee Kee Kim

doi:10.1016/j.neulet.2008.05.018

Phenyl N-t-butylnitrone, a reactive oxygen species scavenger, reduces zymosan-induced visceral pain in rats

Jigong Wang, Victoria Cochran, Salahadin Abdi, Jin Mo Chung, Kyungsoon Chung, Hee Kee Kim

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

To examine a possible involvement of reactive oxygen species (ROS) in visceral pain, the levels of ROS in the colon and the effect of a ROS scavenger phenyl N-t-butylnitrone (PBN) on pain were examined in zymosan-induced colitis rats. Zymosan was instilled into the colon of adult rats. The electromyograms (EMGs) of abdominal muscle contractions in response to colorectal distension (CRD) were recorded as an indicator of visceral pain. After zymosan treatment, the rats showed enhanced EMG and elevated levels of H₂O₂ in the colon. PBN treatment (intraperitoneal, intrathecal or intracolonic) significantly reduced the enhanced EMGs induced by zymosan. The results suggest that elevated ROS in the spinal cord and the colon are involved in visceral pain.

Original language	English (US)
Pages (from-to)	216-219
Number of pages	4
Journal	Neuroscience Letters
Volume	439
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2008.05.018
State	Published - Jul 11 2008
Externally published	Yes

Keywords

Analgesia
Free radical
Hyperalgesia
PBN
ROS
Sensitization

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2008.05.018

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title = "Phenyl N-t-butylnitrone, a reactive oxygen species scavenger, reduces zymosan-induced visceral pain in rats",

abstract = "To examine a possible involvement of reactive oxygen species (ROS) in visceral pain, the levels of ROS in the colon and the effect of a ROS scavenger phenyl N-t-butylnitrone (PBN) on pain were examined in zymosan-induced colitis rats. Zymosan was instilled into the colon of adult rats. The electromyograms (EMGs) of abdominal muscle contractions in response to colorectal distension (CRD) were recorded as an indicator of visceral pain. After zymosan treatment, the rats showed enhanced EMG and elevated levels of H2O2 in the colon. PBN treatment (intraperitoneal, intrathecal or intracolonic) significantly reduced the enhanced EMGs induced by zymosan. The results suggest that elevated ROS in the spinal cord and the colon are involved in visceral pain.",

keywords = "Analgesia, Free radical, Hyperalgesia, PBN, ROS, Sensitization",

author = "Jigong Wang and Victoria Cochran and Salahadin Abdi and Chung, {Jin Mo} and Kyungsoon Chung and Kim, {Hee Kee}",

note = "Funding Information: This work was supported by NIH Grants NS 31680, NS 10161, NS 11255, and AG 13945, and a Research Development Grant from the Sealy Memorial Endowment Fund (2547-03 and 2570-01). The authors sincerely thank June Yowtak for her excellent service in English editing. ",

year = "2008",

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doi = "10.1016/j.neulet.2008.05.018",

language = "English (US)",

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pages = "216--219",

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T1 - Phenyl N-t-butylnitrone, a reactive oxygen species scavenger, reduces zymosan-induced visceral pain in rats

AU - Wang, Jigong

AU - Cochran, Victoria

AU - Abdi, Salahadin

AU - Chung, Jin Mo

AU - Chung, Kyungsoon

AU - Kim, Hee Kee

N1 - Funding Information: This work was supported by NIH Grants NS 31680, NS 10161, NS 11255, and AG 13945, and a Research Development Grant from the Sealy Memorial Endowment Fund (2547-03 and 2570-01). The authors sincerely thank June Yowtak for her excellent service in English editing.

PY - 2008/7/11

Y1 - 2008/7/11

N2 - To examine a possible involvement of reactive oxygen species (ROS) in visceral pain, the levels of ROS in the colon and the effect of a ROS scavenger phenyl N-t-butylnitrone (PBN) on pain were examined in zymosan-induced colitis rats. Zymosan was instilled into the colon of adult rats. The electromyograms (EMGs) of abdominal muscle contractions in response to colorectal distension (CRD) were recorded as an indicator of visceral pain. After zymosan treatment, the rats showed enhanced EMG and elevated levels of H2O2 in the colon. PBN treatment (intraperitoneal, intrathecal or intracolonic) significantly reduced the enhanced EMGs induced by zymosan. The results suggest that elevated ROS in the spinal cord and the colon are involved in visceral pain.

AB - To examine a possible involvement of reactive oxygen species (ROS) in visceral pain, the levels of ROS in the colon and the effect of a ROS scavenger phenyl N-t-butylnitrone (PBN) on pain were examined in zymosan-induced colitis rats. Zymosan was instilled into the colon of adult rats. The electromyograms (EMGs) of abdominal muscle contractions in response to colorectal distension (CRD) were recorded as an indicator of visceral pain. After zymosan treatment, the rats showed enhanced EMG and elevated levels of H2O2 in the colon. PBN treatment (intraperitoneal, intrathecal or intracolonic) significantly reduced the enhanced EMGs induced by zymosan. The results suggest that elevated ROS in the spinal cord and the colon are involved in visceral pain.

KW - Analgesia

KW - Free radical

KW - Hyperalgesia

KW - PBN

KW - ROS

KW - Sensitization

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ER -

Phenyl N-t-butylnitrone, a reactive oxygen species scavenger, reduces zymosan-induced visceral pain in rats

Abstract

Keywords

ASJC Scopus subject areas

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