TY - GEN
T1 - Photoacoustic and thermoacoustic tomography with both optical and electrical contrasts
AU - Ku, Geng
AU - Wang, Lihong V.
PY - 2006
Y1 - 2006
N2 - The absorption of electromagnetic energy causes thermal expansion and induces acoustic waves in biological tissues. Various tissues present particular characteristics in their absorption spectra. To acquire both photoacoustic and thermoacoustic images with multiple contrasts that reflect the absorption of electromagnetic energy, biological tissues are stimulated using laser and microwave pulses, respectively. Muscles with a rich blood supply strongly absorb green optical radiation, which provides excellent optical contrast. High water content tissues, such as connective tissue and muscle tissue, display high contrast to fatty tissues when imaged using microwave radiation. Most cancerous tissues have higher water and ionic concentrations, two characteristics that are also associated with angiogenesis and hemoglobin oxygen saturation. Therefore, cancer diagnosis based on information from tissue properties over an electromagnetic spectrum from microwave to optical bands can be more accurate than was previously available.
AB - The absorption of electromagnetic energy causes thermal expansion and induces acoustic waves in biological tissues. Various tissues present particular characteristics in their absorption spectra. To acquire both photoacoustic and thermoacoustic images with multiple contrasts that reflect the absorption of electromagnetic energy, biological tissues are stimulated using laser and microwave pulses, respectively. Muscles with a rich blood supply strongly absorb green optical radiation, which provides excellent optical contrast. High water content tissues, such as connective tissue and muscle tissue, display high contrast to fatty tissues when imaged using microwave radiation. Most cancerous tissues have higher water and ionic concentrations, two characteristics that are also associated with angiogenesis and hemoglobin oxygen saturation. Therefore, cancer diagnosis based on information from tissue properties over an electromagnetic spectrum from microwave to optical bands can be more accurate than was previously available.
KW - Absorption spectroscopy
KW - Biological tissue
KW - Medical imaging
KW - Optical contrast
KW - Photoacoustic tomography
KW - Radiofrequency contrast
KW - Thermoacoustic tomography
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U2 - 10.1117/12.646365
DO - 10.1117/12.646365
M3 - Conference contribution
AN - SCOPUS:33646191436
SN - 0819461288
SN - 9780819461285
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - Proceedings of SPIE - The International Society for Optical Engineering
T2 - 7th Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - Photons Plus Ultrasound: Imaging and Sensing 2006
Y2 - 22 January 2006 through 26 January 2006
ER -