Photoacoustic Imaging Quantifies Drug Release from Nanocarriers via Redox Chemistry of Dye-Labeled Cargo

Ananthakrishnan Soundaram Jeevarathinam; Jeanne E. Lemaster; Fang Chen; Eric Zhao; Jesse V. Jokerst

doi:10.1002/anie.201914120

Photoacoustic Imaging Quantifies Drug Release from Nanocarriers via Redox Chemistry of Dye-Labeled Cargo

Ananthakrishnan Soundaram Jeevarathinam, Jeanne E. Lemaster, Fang Chen, Eric Zhao, Jesse V. Jokerst

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

We report a new approach to monitor drug release from nanocarriers via a paclitaxel–methylene blue conjugate (PTX-MB) with redox activity. This construct is in a photoacoustically silent reduced state inside poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PTX-MB@PLGA NPs). During release, PTX-MB is spontaneously oxidized to produce a concentration-dependent photoacoustic signal. An in vitro drug-release study showed an initial burst release (25 %) between 0–24 h and a sustained release between 24–120 h with a cumulative release of 40.6 % and a 670-fold increase in photoacoustic signal. An in vivo murine drug release showed a photoacoustic signal enhancement of up to 649 % after 10 hours. PTX-MB@PLGA NPs showed an IC₅₀ of 78 μg mL⁻¹ and 44.7±4.8 % decrease of tumor burden in an orthotopic model of colon cancer via luciferase-positive CT26 cells.

Original language	English (US)
Pages (from-to)	4678-4683
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	59
Issue number	12
DOIs	https://doi.org/10.1002/anie.201914120
State	Published - Mar 16 2020
Externally published	Yes

Keywords

antitumor agents
cancer therapy
drug delivery
paclitaxel
photoacoustic imaging

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201914120

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title = "Photoacoustic Imaging Quantifies Drug Release from Nanocarriers via Redox Chemistry of Dye-Labeled Cargo",

abstract = "We report a new approach to monitor drug release from nanocarriers via a paclitaxel–methylene blue conjugate (PTX-MB) with redox activity. This construct is in a photoacoustically silent reduced state inside poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PTX-MB@PLGA NPs). During release, PTX-MB is spontaneously oxidized to produce a concentration-dependent photoacoustic signal. An in vitro drug-release study showed an initial burst release (25 %) between 0–24 h and a sustained release between 24–120 h with a cumulative release of 40.6 % and a 670-fold increase in photoacoustic signal. An in vivo murine drug release showed a photoacoustic signal enhancement of up to 649 % after 10 hours. PTX-MB@PLGA NPs showed an IC50 of 78 μg mL−1 and 44.7±4.8 % decrease of tumor burden in an orthotopic model of colon cancer via luciferase-positive CT26 cells.",

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AU - Zhao, Eric

AU - Jokerst, Jesse V.

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Photoacoustic Imaging Quantifies Drug Release from Nanocarriers via Redox Chemistry of Dye-Labeled Cargo

Abstract

Keywords

ASJC Scopus subject areas

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