@inproceedings{771068cb4a3c4b9685ba2a4e4bc35a5f,
title = "Photoacoustic microscopy with submicron resolution",
abstract = "We show that it is possible to obtain high optical contrast photoacoustic images of tissue with 0.55 μm transverse resolution. To achieve high sensitivity, we used a high NA (0.85), 125 MHz spherically focused ultrasonic transducer in a confocal arrangement with a high resolution optical objective (NA=0.6). Laser pulses of a few nJ in pulse energy with durations of 1.5 ns at a 20 KHz pulse repetition rate were used to generate photoacoustic waves. Although the penetration depth is limited to hundreds of microns by both optical scattering and ultrasonic absorption, the developed technique can compete with optical microscopy, for example, in quantitative spectral measurements, in microcirculation research, or in nanoparticle detection.",
keywords = "Functional imaging, Longitudinal studies, Microcirculation, Noninvasive imaging, Photoacoustic imaging, Photoacoustic microscopy",
author = "Konstantin Maslov and Geng Ku and Wang, {Lihong V.}",
year = "2010",
month = feb,
day = "11",
doi = "10.1117/12.841919",
language = "English (US)",
isbn = "9780819479600",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
booktitle = "Photons Plus Ultrasound",
note = "Photons Plus Ultrasound: Imaging and Sensing 2010 ; Conference date: 24-01-2010 Through 26-01-2010",
}