Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain

Yiwen Wang; Xueyi Xie; Xueding Wang; Geng Ku; Kelly L. Gill; D. Patrick O'Neal; George Stoica; Lihong V. Wang

doi:10.1021/nl049126a

Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain

Yiwen Wang, Xueyi Xie, Xueding Wang, Geng Ku, Kelly L. Gill, D. Patrick O'Neal, George Stoica, Lihong V. Wang

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

437 Scopus citations

Abstract

This study demonstrates the feasibility of using nanoshells in vivo as a new contrast-enhancing agent for photoacoustic tomography. Deep penetrating near-infrared light was employed to image the in vivo distribution of poly(ethylene glycol)-coated nanoshells circulating in the vasculature of a rat brain. The images, captured after three sequential administrations of nanoshells, present a gradual enhancement of the optical absorption in the brain vessels by up to 63%. Subsequent clearance of the nanoshells from the blood was imaged for ∼6 h after the administrations.

Original language	English (US)
Pages (from-to)	1689-1692
Number of pages	4
Journal	Nano Letters
Volume	4
Issue number	9
DOIs	https://doi.org/10.1021/nl049126a
State	Published - Sep 2004

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

Access to Document

10.1021/nl049126a

Cite this

@article{ae88a8d85f0c4a97bea551a8eaa98006,

title = "Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain",

abstract = "This study demonstrates the feasibility of using nanoshells in vivo as a new contrast-enhancing agent for photoacoustic tomography. Deep penetrating near-infrared light was employed to image the in vivo distribution of poly(ethylene glycol)-coated nanoshells circulating in the vasculature of a rat brain. The images, captured after three sequential administrations of nanoshells, present a gradual enhancement of the optical absorption in the brain vessels by up to 63%. Subsequent clearance of the nanoshells from the blood was imaged for ∼6 h after the administrations.",

author = "Yiwen Wang and Xueyi Xie and Xueding Wang and Geng Ku and Gill, {Kelly L.} and O'Neal, {D. Patrick} and George Stoica and Wang, {Lihong V.}",

year = "2004",

month = sep,

doi = "10.1021/nl049126a",

language = "English (US)",

volume = "4",

pages = "1689--1692",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "9",

}

TY - JOUR

T1 - Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain

AU - Wang, Yiwen

AU - Xie, Xueyi

AU - Wang, Xueding

AU - Ku, Geng

AU - Gill, Kelly L.

AU - O'Neal, D. Patrick

AU - Stoica, George

AU - Wang, Lihong V.

PY - 2004/9

Y1 - 2004/9

N2 - This study demonstrates the feasibility of using nanoshells in vivo as a new contrast-enhancing agent for photoacoustic tomography. Deep penetrating near-infrared light was employed to image the in vivo distribution of poly(ethylene glycol)-coated nanoshells circulating in the vasculature of a rat brain. The images, captured after three sequential administrations of nanoshells, present a gradual enhancement of the optical absorption in the brain vessels by up to 63%. Subsequent clearance of the nanoshells from the blood was imaged for ∼6 h after the administrations.

AB - This study demonstrates the feasibility of using nanoshells in vivo as a new contrast-enhancing agent for photoacoustic tomography. Deep penetrating near-infrared light was employed to image the in vivo distribution of poly(ethylene glycol)-coated nanoshells circulating in the vasculature of a rat brain. The images, captured after three sequential administrations of nanoshells, present a gradual enhancement of the optical absorption in the brain vessels by up to 63%. Subsequent clearance of the nanoshells from the blood was imaged for ∼6 h after the administrations.

UR - http://www.scopus.com/inward/record.url?scp=4644265751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4644265751&partnerID=8YFLogxK

U2 - 10.1021/nl049126a

DO - 10.1021/nl049126a

M3 - Article

AN - SCOPUS:4644265751

SN - 1530-6984

VL - 4

SP - 1689

EP - 1692

JO - Nano Letters

JF - Nano Letters

IS - 9

ER -

Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this