@article{271b4b1ed92d4596ab8a3eb5658c30b3,
title = "PI3 Kinase Signals BCR-Dependent Mature B Cell Survival",
abstract = "Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with the FOXO1 transcription factor playing a central role.",
keywords = "MOLIMMUNO, SIGNALING",
author = "Lakshmi Srinivasan and Yoshiteru Sasaki and Calado, {Dinis Pedro} and Baochun Zhang and Paik, {Ji Hye} and DePinho, {Ronald A.} and Kutok, {Jeffrey L.} and Kearney, {John F.} and Otipoby, {Kevin L.} and Klaus Rajewsky",
note = "Funding Information: We thank D. Ghitza, A. Pellerin, A. Monti, A.Tetreault, J. Grundy, J. Wang, J. Xia and W.F. Jia for expert technical assistance; E. Derudder for reagents; all Rajewsky lab members for discussions; and M. Janz for critical reading of the manuscript; A. Klippel for the MP110 ∗ cDNA; and K. Kaibuchi for Rac1DA cDNA. K.R. is supported by NIH grants AI054636 and CA092625, the Leukemia and Lymphoma Society and the European Union through MUGEN; L.S. by the T32 training grant of the Joint Program in Hematology and Transfusion Medicine at Harvard Medical School; J.F.K. by NIH grant AI014782-31; D.P.C. by a postdoctoral fellowship from the Portuguese Foundation for Science and Technology (FCT-MCES); B.Z. by a postdoctoral fellowship of the Leukemia and Lymphoma Society; and RAD by the NIH and the Robert A. and Renee E. Belfer Foundation. ",
year = "2009",
month = oct,
day = "30",
doi = "10.1016/j.cell.2009.08.041",
language = "English (US)",
volume = "139",
pages = "573--586",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "3",
}