Pilot study of neurologic toxicity in mice after proton minibeam therapy

John G. Eley; Awalpreet S. Chadha; Caio Quini; Elisabeth G. Vichaya; Cancan Zhang; James Davis; Narayan Sahoo; Jaylyn Waddell; Dominic Leiser; F. Avraham Dilmanian; Sunil Krishnan

doi:10.1038/s41598-020-68015-0

Pilot study of neurologic toxicity in mice after proton minibeam therapy

John G. Eley, Awalpreet S. Chadha, Caio Quini, Elisabeth G. Vichaya, Cancan Zhang, James Davis, Narayan Sahoo, Jaylyn Waddell, Dominic Leiser, F. Avraham Dilmanian, Sunil Krishnan

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Abstract

Proton minibeams (MBs) comprised of parallel planar beamlets were evaluated for their ability to spare healthy brain compared to proton broad beams (BBs). Juvenile mice were given partial brain irradiation of 10 or 30 Gy integral dose using 100 MeV protons configured either as BBs or arrays of 0.3-mm planar MBs spaced 1.0 mm apart on center. Neurologic toxicity was evaluated during an 8-month surveillance: no overt constitutional or neurologic dysfunction was noted for any study animals. Less acute epilation was observed in MB than BB mice. Persistent chronic inflammation was noted along the entire BB path in BB mice whereas inflammation was confined to just within the MB peak regions in MB mice. The potential neurologic sparing, possibly via reduced volume of chronic inflammation, offers a compelling rationale for clinical advancement of this proton technique.

Original language	English (US)
Article number	11368
Journal	Scientific reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-020-68015-0
State	Published - Dec 1 2020

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title = "Pilot study of neurologic toxicity in mice after proton minibeam therapy",

abstract = "Proton minibeams (MBs) comprised of parallel planar beamlets were evaluated for their ability to spare healthy brain compared to proton broad beams (BBs). Juvenile mice were given partial brain irradiation of 10 or 30 Gy integral dose using 100 MeV protons configured either as BBs or arrays of 0.3-mm planar MBs spaced 1.0 mm apart on center. Neurologic toxicity was evaluated during an 8-month surveillance: no overt constitutional or neurologic dysfunction was noted for any study animals. Less acute epilation was observed in MB than BB mice. Persistent chronic inflammation was noted along the entire BB path in BB mice whereas inflammation was confined to just within the MB peak regions in MB mice. The potential neurologic sparing, possibly via reduced volume of chronic inflammation, offers a compelling rationale for clinical advancement of this proton technique.",

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doi = "10.1038/s41598-020-68015-0",

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AU - Eley, John G.

AU - Chadha, Awalpreet S.

AU - Quini, Caio

AU - Vichaya, Elisabeth G.

AU - Zhang, Cancan

AU - Davis, James

AU - Sahoo, Narayan

AU - Waddell, Jaylyn

AU - Leiser, Dominic

AU - Dilmanian, F. Avraham

AU - Krishnan, Sunil

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Proton minibeams (MBs) comprised of parallel planar beamlets were evaluated for their ability to spare healthy brain compared to proton broad beams (BBs). Juvenile mice were given partial brain irradiation of 10 or 30 Gy integral dose using 100 MeV protons configured either as BBs or arrays of 0.3-mm planar MBs spaced 1.0 mm apart on center. Neurologic toxicity was evaluated during an 8-month surveillance: no overt constitutional or neurologic dysfunction was noted for any study animals. Less acute epilation was observed in MB than BB mice. Persistent chronic inflammation was noted along the entire BB path in BB mice whereas inflammation was confined to just within the MB peak regions in MB mice. The potential neurologic sparing, possibly via reduced volume of chronic inflammation, offers a compelling rationale for clinical advancement of this proton technique.

AB - Proton minibeams (MBs) comprised of parallel planar beamlets were evaluated for their ability to spare healthy brain compared to proton broad beams (BBs). Juvenile mice were given partial brain irradiation of 10 or 30 Gy integral dose using 100 MeV protons configured either as BBs or arrays of 0.3-mm planar MBs spaced 1.0 mm apart on center. Neurologic toxicity was evaluated during an 8-month surveillance: no overt constitutional or neurologic dysfunction was noted for any study animals. Less acute epilation was observed in MB than BB mice. Persistent chronic inflammation was noted along the entire BB path in BB mice whereas inflammation was confined to just within the MB peak regions in MB mice. The potential neurologic sparing, possibly via reduced volume of chronic inflammation, offers a compelling rationale for clinical advancement of this proton technique.

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Pilot study of neurologic toxicity in mice after proton minibeam therapy

Abstract

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