@article{7e11671606a34065934fe9794afc7595,
title = "Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2",
abstract = "Previous reports show that the desmosomal plaque protein plakophilin3 (PKP3) is essential for desmosome formation. Here, we report that PKP3 over-expression decreases calcium dependency for de novo desmosome formation and makes existing cell-cell adhesion junctions more resilient in low calcium medium due to an increase in desmocollin2 expression. PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins.",
keywords = "Adhesion, Desmocollin 2, Desmosome, Plakophilin 3",
author = "Mansa Gurjar and Kumarkrishna Raychaudhuri and Snehal Mahadik and Divya Reddy and Apurva Atak and Trupti Shetty and Kruthi Rao and Karkhanis, {Mansi S.} and Prajakta Gosavi and Lalit Sehgal and Sanjay Gupta and Dalal, {Sorab N.}",
note = "Funding Information: We thank Dr. Vidita Vaidya and Dr. Sudipta Maiti for providing time on their confocal microscopes. We thank Dr. Shubha Tole for providing the Renilla luciferase pRL-TK plasmid. We thank the ACTREC light microscopy and electron microscopy departments for help with image acquisition. MG and KR1 were supported by fellowships from the Council for Scientific and Industrial Research . The work was supported by a grant from the Department of Biotechnology, Government of India to SND ( BT/PR11537/BRB/10/661/2008 ). Funding Information: We thank Dr. Vidita Vaidya and Dr. Sudipta Maiti for providing time on their confocal microscopes. We thank Dr. Shubha Tole for providing the Renilla luciferase pRL-TK plasmid. We thank the ACTREC light microscopy and electron microscopy departments for help with image acquisition. MG and KR1 were supported by fellowships from the Council for Scientific and Industrial Research. The work was supported by a grant from the Department of Biotechnology, Government of India to SND (BT/PR11537/BRB/10/661/2008). Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",
year = "2018",
month = jan,
day = "1",
doi = "10.1016/j.bbrc.2017.11.085",
language = "English (US)",
volume = "495",
pages = "768--774",
journal = "Biochemical and biophysical research communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "1",
}