TY - JOUR
T1 - Plasma vitamins E and A and risk of bladder cancer
T2 - A case-control analysis
AU - Liang, Dong
AU - Lin, Jie
AU - Grossman, H. Barton
AU - Ma, Jing
AU - Wei, Bo
AU - Dinney, Colin P.
AU - Wu, Xifeng
PY - 2008/11
Y1 - 2008/11
N2 - Objective: Current results on the association between serum micronutrients and bladder cancer risk have been inconsistent. We assessed plasma vitamin E (α-tocopherol, and γ-tocopherol), vitamin A (retinol), and bladder cancer risk using data collected from a case-control study. Methods: Epidemiologic data were collected via in-person interview. Plasma concentrations of α-tocopherol, γ-tocopherol, and retinol were determined by a high-performance liquid chromatography assay. Multivariate logistic regression analyses were used to estimate bladder cancer risk in association with plasma vitamins E and A. Results: 386 bladder cancer patients and 389 age-, gender-, and ethnicity-matched controls were included in the study. The mean plasma α-tocopherol and retinol were significantly lower in cases than in controls (α-tocopherol: 23.93 μg/ml vs. 27.48 μg/ml, P < 0.001; retinol: 1.41 μg/ml vs. 1.53 μg/ml, P < 0.001). There was a significant reduction in bladder cancer risk associated with increasing plasma α-tocopherol level (Adjusted OR: 0.91; 95% CI: 0.85-0.97). In quartile analysis, using subjects with the lowest α-tocopherol level as the reference group, the adjusted ORs and 95% CIs for the second, third, and fourth quartiles were 0.75 (0.50-1.14), 0.69 (0.46-1.05), and 0.50 (0.32-0.78), respectively (P for trend = 0.003). Increased retinol level was also associated with reduced risk with OR of 0.57 (95% CI: 0.40-0.81). The ORs and 95% CIs for the second, third, and fourth quartiles were 0.92 (0.61-1.39), 0.66 (0.43-1.01), and 0.62 (0.40-0.95), respectively, with significant dose-response trend (P for trend = 0.01). Finally, there were significant correlations between plasma levels and dietary intakes for the three micronutrients. Conclusion: Our results suggest potential protective effect of α-tocopherol and retinol on bladder cancer risk. Future large prospective studies are needed to confirm the findings.
AB - Objective: Current results on the association between serum micronutrients and bladder cancer risk have been inconsistent. We assessed plasma vitamin E (α-tocopherol, and γ-tocopherol), vitamin A (retinol), and bladder cancer risk using data collected from a case-control study. Methods: Epidemiologic data were collected via in-person interview. Plasma concentrations of α-tocopherol, γ-tocopherol, and retinol were determined by a high-performance liquid chromatography assay. Multivariate logistic regression analyses were used to estimate bladder cancer risk in association with plasma vitamins E and A. Results: 386 bladder cancer patients and 389 age-, gender-, and ethnicity-matched controls were included in the study. The mean plasma α-tocopherol and retinol were significantly lower in cases than in controls (α-tocopherol: 23.93 μg/ml vs. 27.48 μg/ml, P < 0.001; retinol: 1.41 μg/ml vs. 1.53 μg/ml, P < 0.001). There was a significant reduction in bladder cancer risk associated with increasing plasma α-tocopherol level (Adjusted OR: 0.91; 95% CI: 0.85-0.97). In quartile analysis, using subjects with the lowest α-tocopherol level as the reference group, the adjusted ORs and 95% CIs for the second, third, and fourth quartiles were 0.75 (0.50-1.14), 0.69 (0.46-1.05), and 0.50 (0.32-0.78), respectively (P for trend = 0.003). Increased retinol level was also associated with reduced risk with OR of 0.57 (95% CI: 0.40-0.81). The ORs and 95% CIs for the second, third, and fourth quartiles were 0.92 (0.61-1.39), 0.66 (0.43-1.01), and 0.62 (0.40-0.95), respectively, with significant dose-response trend (P for trend = 0.01). Finally, there were significant correlations between plasma levels and dietary intakes for the three micronutrients. Conclusion: Our results suggest potential protective effect of α-tocopherol and retinol on bladder cancer risk. Future large prospective studies are needed to confirm the findings.
KW - Bladder cancer
KW - Case-control study
KW - Plasma
KW - Vitamins A, E
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U2 - 10.1007/s10552-008-9165-2
DO - 10.1007/s10552-008-9165-2
M3 - Article
C2 - 18478342
AN - SCOPUS:52549107704
SN - 0957-5243
VL - 19
SP - 981
EP - 992
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 9
ER -