TY - JOUR
T1 - Plasmablastic lymphoma involving the penis
T2 - A previously unreported location of a case with aberrant CD3 expression
AU - Sun, Jianlan
AU - Medeiros, L. Jeffrey
AU - Lin, Pei
AU - Lu, Gary
AU - Bueso-Ramos, Carlos E.
AU - You, M. James
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2011/1
Y1 - 2011/1
N2 - Lymphomas of the penis are rare and can either arise at this site or be a manifestation of systemic disease. We report the case of an elderly man with a plasmablastic lymphoma (PBL) involving the uncircumcised penile prepuce. The neoplasm was composed of plasmablasts positive for monotypic immunoglobulin lambda light chain, CD3, CD79a, CD138 and Epstein-Barr virus encoded RNA (EBER), and was negative for CD2, CD5, CD7, CD20, and PAX5. This case is highly unusual for at least two reasons. The penile foreskin is a rare location for lymphoma and PBL at this site has not been reported. Secondly, the tumour was shown by immunohistochemistry to be positive for the T-cell marker CD3. Lineage ambiguity in terminally differentiated B-cell lymphomas has been reported to be closely related with immune compromise and is associated with Epstein-Barr virus infection. The literature on penile lymphomas is also reviewed.
AB - Lymphomas of the penis are rare and can either arise at this site or be a manifestation of systemic disease. We report the case of an elderly man with a plasmablastic lymphoma (PBL) involving the uncircumcised penile prepuce. The neoplasm was composed of plasmablasts positive for monotypic immunoglobulin lambda light chain, CD3, CD79a, CD138 and Epstein-Barr virus encoded RNA (EBER), and was negative for CD2, CD5, CD7, CD20, and PAX5. This case is highly unusual for at least two reasons. The penile foreskin is a rare location for lymphoma and PBL at this site has not been reported. Secondly, the tumour was shown by immunohistochemistry to be positive for the T-cell marker CD3. Lineage ambiguity in terminally differentiated B-cell lymphomas has been reported to be closely related with immune compromise and is associated with Epstein-Barr virus infection. The literature on penile lymphomas is also reviewed.
KW - Epstein-Barr virus
KW - Immunohistochemistry
KW - Plasmablastic lymphoma
UR - http://www.scopus.com/inward/record.url?scp=80052213530&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052213530&partnerID=8YFLogxK
U2 - 10.1097/PAT.0b013e328340bbba
DO - 10.1097/PAT.0b013e328340bbba
M3 - Review article
C2 - 21240066
AN - SCOPUS:80052213530
SN - 0031-3025
VL - 43
SP - 54
EP - 57
JO - Pathology
JF - Pathology
IS - 1
ER -