TY - JOUR
T1 - Plasmacytoid dendritic cells
T2 - Sensing nucleic acids in viral infection and autoimmune diseases
AU - Gilliet, Michel
AU - Cao, Wei
AU - Liu, Yong Jun
N1 - Funding Information:
We thank the former and current members of the laboratory for their critical contributions, the M.D. Anderson Cancer Foundation and The Dana Foundation for financial support, M. Haject for editorial assistance, T. Kim, M. Bao and K. Arima for critical reading of the manuscript. This Review is dedicated to Dr Ralph Steinman for his support and encouragement.
PY - 2008/8
Y1 - 2008/8
N2 - Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection. This function of pDCs is linked to their expression of Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids within the early endosomes. Exclusion of self nucleic acids from TLR-containing early endosomes normally prevents pDC responses to them. However, in some autoimmune diseases, self nucleic acids can be modified by host factors and gain entrance to pDC endosomes, where they activate TLR signalling. Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis.
AB - Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection. This function of pDCs is linked to their expression of Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids within the early endosomes. Exclusion of self nucleic acids from TLR-containing early endosomes normally prevents pDC responses to them. However, in some autoimmune diseases, self nucleic acids can be modified by host factors and gain entrance to pDC endosomes, where they activate TLR signalling. Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis.
UR - http://www.scopus.com/inward/record.url?scp=48749085127&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48749085127&partnerID=8YFLogxK
U2 - 10.1038/nri2358
DO - 10.1038/nri2358
M3 - Review article
C2 - 18641647
AN - SCOPUS:48749085127
SN - 1474-1733
VL - 8
SP - 594
EP - 606
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 8
ER -