Plasmacytoid Urothelial Carcinoma of the Urinary Bladder: A Clinicopathologic and Immunohistochemical Analysis of 49 Cases

Melanie D Fox; Li Xiao; Miao Zhang; Ashish M Kamat; Arlene Siefker-Radtke; Li Zhang; Colin P Dinney; Bogdan Czerniak; Charles C Guo

doi:10.1093/ajcp/aqx029

Plasmacytoid Urothelial Carcinoma of the Urinary Bladder: A Clinicopathologic and Immunohistochemical Analysis of 49 Cases

Melanie D Fox, Li Xiao, Miao Zhang, Ashish M Kamat, Arlene Siefker-Radtke, Li Zhang, Colin P Dinney, Bogdan Czerniak, Charles C Guo

Pathology

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Objectives: Plasmacytoid urothelial carcinoma (PUC) of the bladder is a rare histologic variant. We retrospectively analyzed a large series of bladder PUC from a single institution.

Methods: The patients consisted of 44 men and five women with a mean age of 62 years (range, 45-86 years).

Results: PUC was pure in 23 cases and mixed with other histologic types in 26 cases. All PUCs diffusely invaded the bladder wall. Most PUCs lacked immunoreactivity for the retinoblastoma (RB) gene protein (12/32) and E-cadherin (8/30). Of the 44 patients with follow-up information, 25 died of PUC at a mean of 23 months, whereas 19 patients were alive at a mean of 22 months.

Conclusions: Our findings support that bladder PUC is a highly aggressive disease. The lack of E-cadherin expression in PUCs may underlie the distinct discohesive histologic appearance, and abnormal function of the RB gene may be implicated in the development of PUC.

Original language	English (US)
Journal	American Journal of Clinical Pathology
DOIs	https://doi.org/10.1093/ajcp/aqx029
State	E-pub ahead of print - Mar 23 2017

Keywords

Journal Article

Access to Document

10.1093/ajcp/aqx029

Cite this

@article{ad75304c9650439592ce26d0e434371b,

title = "Plasmacytoid Urothelial Carcinoma of the Urinary Bladder: A Clinicopathologic and Immunohistochemical Analysis of 49 Cases",

abstract = "Objectives: Plasmacytoid urothelial carcinoma (PUC) of the bladder is a rare histologic variant. We retrospectively analyzed a large series of bladder PUC from a single institution.Methods: The patients consisted of 44 men and five women with a mean age of 62 years (range, 45-86 years).Results: PUC was pure in 23 cases and mixed with other histologic types in 26 cases. All PUCs diffusely invaded the bladder wall. Most PUCs lacked immunoreactivity for the retinoblastoma (RB) gene protein (12/32) and E-cadherin (8/30). Of the 44 patients with follow-up information, 25 died of PUC at a mean of 23 months, whereas 19 patients were alive at a mean of 22 months.Conclusions: Our findings support that bladder PUC is a highly aggressive disease. The lack of E-cadherin expression in PUCs may underlie the distinct discohesive histologic appearance, and abnormal function of the RB gene may be implicated in the development of PUC.",

keywords = "Journal Article",

author = "Fox, {Melanie D} and Li Xiao and Miao Zhang and Kamat, {Ashish M} and Arlene Siefker-Radtke and Li Zhang and Dinney, {Colin P} and Bogdan Czerniak and Guo, {Charles C}",

year = "2017",

month = mar,

day = "23",

doi = "10.1093/ajcp/aqx029",

language = "English (US)",

journal = "American Journal of Clinical Pathology",

issn = "0002-9173",

publisher = "American Society of Clinical Pathologists",

}

TY - JOUR

T1 - Plasmacytoid Urothelial Carcinoma of the Urinary Bladder

T2 - A Clinicopathologic and Immunohistochemical Analysis of 49 Cases

AU - Fox, Melanie D

AU - Xiao, Li

AU - Zhang, Miao

AU - Kamat, Ashish M

AU - Siefker-Radtke, Arlene

AU - Zhang, Li

AU - Dinney, Colin P

AU - Czerniak, Bogdan

AU - Guo, Charles C

PY - 2017/3/23

Y1 - 2017/3/23

N2 - Objectives: Plasmacytoid urothelial carcinoma (PUC) of the bladder is a rare histologic variant. We retrospectively analyzed a large series of bladder PUC from a single institution.Methods: The patients consisted of 44 men and five women with a mean age of 62 years (range, 45-86 years).Results: PUC was pure in 23 cases and mixed with other histologic types in 26 cases. All PUCs diffusely invaded the bladder wall. Most PUCs lacked immunoreactivity for the retinoblastoma (RB) gene protein (12/32) and E-cadherin (8/30). Of the 44 patients with follow-up information, 25 died of PUC at a mean of 23 months, whereas 19 patients were alive at a mean of 22 months.Conclusions: Our findings support that bladder PUC is a highly aggressive disease. The lack of E-cadherin expression in PUCs may underlie the distinct discohesive histologic appearance, and abnormal function of the RB gene may be implicated in the development of PUC.

AB - Objectives: Plasmacytoid urothelial carcinoma (PUC) of the bladder is a rare histologic variant. We retrospectively analyzed a large series of bladder PUC from a single institution.Methods: The patients consisted of 44 men and five women with a mean age of 62 years (range, 45-86 years).Results: PUC was pure in 23 cases and mixed with other histologic types in 26 cases. All PUCs diffusely invaded the bladder wall. Most PUCs lacked immunoreactivity for the retinoblastoma (RB) gene protein (12/32) and E-cadherin (8/30). Of the 44 patients with follow-up information, 25 died of PUC at a mean of 23 months, whereas 19 patients were alive at a mean of 22 months.Conclusions: Our findings support that bladder PUC is a highly aggressive disease. The lack of E-cadherin expression in PUCs may underlie the distinct discohesive histologic appearance, and abnormal function of the RB gene may be implicated in the development of PUC.

KW - Journal Article

U2 - 10.1093/ajcp/aqx029

DO - 10.1093/ajcp/aqx029

M3 - Article

C2 - 28371875

SN - 0002-9173

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

ER -

Plasmacytoid Urothelial Carcinoma of the Urinary Bladder: A Clinicopathologic and Immunohistochemical Analysis of 49 Cases

Abstract

Keywords

Access to Document

Fingerprint

Cite this