Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques

Bo Wang, Evgeniya Yantsen, Timothy Larson, Andrei B. Karpiouk, Shriram Sethuraman, Jimmy L. Su, Konstantin Sokolov, Stanislav Y. Emelianov

Research output: Contribution to journalArticlepeer-review

188 Scopus citations

Abstract

To detect macrophages in atherosclerotic plaques, plasmonic gold nanoparticles are introduced as a contrast agent for intravascular photoacoustic imaging. The phantom and ex vivo tissue studies show that the individual spherical nanoparticles, resonant at 530 nm wavelength, produce a weak photoacoustic signal at 680 nm wavelength while photoacoustic signal from nanoparticles internalized by macrophages is very strong due to the plasmon resonance coupling effect. These results suggest that intravascular photoacoustic imaging can assess the macrophage-mediated aggregation of nanoparticles and therefore identify the presence and the location of nanoparticles associated with macrophage-rich atherosclerotic plaques.

Original languageEnglish (US)
Pages (from-to)2212-2217
Number of pages6
JournalNano Letters
Volume9
Issue number6
DOIs
StatePublished - Jun 10 2009

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanical Engineering

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