Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells

Ekaterina Y. Lukianova-Hleb; Andrey Belyanin; Shruti Kashinath; Xiangwei Wu; Dmitri O. Lapotko

doi:10.1016/j.biomaterials.2011.11.015

Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells

Ekaterina Y. Lukianova-Hleb, Andrey Belyanin, Shruti Kashinath, Xiangwei Wu, Dmitri O. Lapotko

Clinical Cancer Prevention

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

Cancer chemotherapies suffer from multi drug resistance, high non-specific toxicity and heterogeneity of tumors. We report a method of plasmonic nanobubble-enhanced endosomal escape (PNBEE) for the selective, fast and guided intracellular delivery of drugs through a self-assembly by cancer cells of separately targeted gold nanoparticles and encapsulated drug (Doxil). The co-localized with Doxil plasmonic nanobubbles optically generated in cancer cells released the drug into the cytoplasm thus increasing the therapeutic efficacy against these drug-resistant cells by 31-fold, reducing drug dose by 20-fold, the treatment time by 3-fold and the non-specific toxicity by 10-fold compared to standard treatment. Thus the PNBEE mechanism provided selective, safe and efficient intracellular drug delivery in heterogeneous environment opening new opportunities for drug therapies.

Original language	English (US)
Pages (from-to)	1821-1826
Number of pages	6
Journal	Biomaterials
Volume	33
Issue number	6
DOIs	https://doi.org/10.1016/j.biomaterials.2011.11.015
State	Published - Feb 2012

Keywords

Drug delivery
Drug release
Gold
Laser
Liposome
Nanoparticle

ASJC Scopus subject areas

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

Access to Document

10.1016/j.biomaterials.2011.11.015

Cite this

@article{38178bea1ba148b98fbd7b8e54e82f3c,

title = "Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells",

abstract = "Cancer chemotherapies suffer from multi drug resistance, high non-specific toxicity and heterogeneity of tumors. We report a method of plasmonic nanobubble-enhanced endosomal escape (PNBEE) for the selective, fast and guided intracellular delivery of drugs through a self-assembly by cancer cells of separately targeted gold nanoparticles and encapsulated drug (Doxil). The co-localized with Doxil plasmonic nanobubbles optically generated in cancer cells released the drug into the cytoplasm thus increasing the therapeutic efficacy against these drug-resistant cells by 31-fold, reducing drug dose by 20-fold, the treatment time by 3-fold and the non-specific toxicity by 10-fold compared to standard treatment. Thus the PNBEE mechanism provided selective, safe and efficient intracellular drug delivery in heterogeneous environment opening new opportunities for drug therapies.",

keywords = "Drug delivery, Drug release, Gold, Laser, Liposome, Nanoparticle",

author = "Lukianova-Hleb, {Ekaterina Y.} and Andrey Belyanin and Shruti Kashinath and Xiangwei Wu and Lapotko, {Dmitri O.}",

note = "Funding Information: Authors thank Drs. Joseph Zasadzinski of the University of Minnesota and Dr. Gary Braun of the University of California Santa Barbara for their help with the fabrication of hollow gold nanoshells, Dr. Xiaoyang Ren of the UT MD Anderson Cancer Center for his help with cell culturing and Dr. Daniel Wagner of Rice University for valuable discussions of the method. Ms. Sue Parminter kindly copy-edited this manuscript. This work was supported in part by National Institute of Health Grant R01GM094816 . Confocal microscopy was performed on equipment obtained through a Shared Instrumentation Grant from the National Institutes of Health ( S10RR026399-01 ).",

year = "2012",

month = feb,

doi = "10.1016/j.biomaterials.2011.11.015",

language = "English (US)",

volume = "33",

pages = "1821--1826",

journal = "Biomaterials",

issn = "0142-9612",

publisher = "Elsevier BV",

number = "6",

}

TY - JOUR

T1 - Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells

AU - Lukianova-Hleb, Ekaterina Y.

AU - Belyanin, Andrey

AU - Kashinath, Shruti

AU - Wu, Xiangwei

AU - Lapotko, Dmitri O.

N1 - Funding Information: Authors thank Drs. Joseph Zasadzinski of the University of Minnesota and Dr. Gary Braun of the University of California Santa Barbara for their help with the fabrication of hollow gold nanoshells, Dr. Xiaoyang Ren of the UT MD Anderson Cancer Center for his help with cell culturing and Dr. Daniel Wagner of Rice University for valuable discussions of the method. Ms. Sue Parminter kindly copy-edited this manuscript. This work was supported in part by National Institute of Health Grant R01GM094816 . Confocal microscopy was performed on equipment obtained through a Shared Instrumentation Grant from the National Institutes of Health ( S10RR026399-01 ).

PY - 2012/2

Y1 - 2012/2

N2 - Cancer chemotherapies suffer from multi drug resistance, high non-specific toxicity and heterogeneity of tumors. We report a method of plasmonic nanobubble-enhanced endosomal escape (PNBEE) for the selective, fast and guided intracellular delivery of drugs through a self-assembly by cancer cells of separately targeted gold nanoparticles and encapsulated drug (Doxil). The co-localized with Doxil plasmonic nanobubbles optically generated in cancer cells released the drug into the cytoplasm thus increasing the therapeutic efficacy against these drug-resistant cells by 31-fold, reducing drug dose by 20-fold, the treatment time by 3-fold and the non-specific toxicity by 10-fold compared to standard treatment. Thus the PNBEE mechanism provided selective, safe and efficient intracellular drug delivery in heterogeneous environment opening new opportunities for drug therapies.

AB - Cancer chemotherapies suffer from multi drug resistance, high non-specific toxicity and heterogeneity of tumors. We report a method of plasmonic nanobubble-enhanced endosomal escape (PNBEE) for the selective, fast and guided intracellular delivery of drugs through a self-assembly by cancer cells of separately targeted gold nanoparticles and encapsulated drug (Doxil). The co-localized with Doxil plasmonic nanobubbles optically generated in cancer cells released the drug into the cytoplasm thus increasing the therapeutic efficacy against these drug-resistant cells by 31-fold, reducing drug dose by 20-fold, the treatment time by 3-fold and the non-specific toxicity by 10-fold compared to standard treatment. Thus the PNBEE mechanism provided selective, safe and efficient intracellular drug delivery in heterogeneous environment opening new opportunities for drug therapies.

KW - Drug delivery

KW - Drug release

KW - Gold

KW - Laser

KW - Liposome

KW - Nanoparticle

UR - http://www.scopus.com/inward/record.url?scp=83555178368&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=83555178368&partnerID=8YFLogxK

U2 - 10.1016/j.biomaterials.2011.11.015

DO - 10.1016/j.biomaterials.2011.11.015

M3 - Article

C2 - 22137124

AN - SCOPUS:83555178368

SN - 0142-9612

VL - 33

SP - 1821

EP - 1826

JO - Biomaterials

JF - Biomaterials

IS - 6

ER -

Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this